ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2015
The use of the MeDALL-chip to assess IgE sensitization: a new diagnostic tool for allergic disease?
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Maternal allergen-specific IgG might protect the child against allergic sensitization.The Journal of allergy and clinical immunology · 2019Trial
- Decoding allergy in vitro: Challenges and clinical use of humoral and cellular methods.Allergologie select · 2026Review
- Concordance between different methods of detecting fungal-specific IgE antibody in asthma.Frontiers in allergy · 2026Article
- From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.Frontiers in allergy · 2025Review
- Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis.Turkish archives of pediatrics · 2023Article
- Profound differences in IgE and IgG recognition of micro-arrayed allergens in hyper-IgE syndromes.Allergy · 2022Article
- Review
- Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?Nature reviews. Immunology · 2021Review
- The use of microarray and other multiplex technologies in the diagnosis of allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- Article
- Machine Learning-Empowered FTIR Spectroscopy Serum Analysis Stratifies Healthy, Allergic, and SIT-Treated Mice and Humans.Biomolecules · 2020Article
- Toward personalization of asthma treatment according to trigger factors.The Journal of allergy and clinical immunology · 2020Review
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.The World Allergy Organization journal · 2020Article
- IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo.The World Allergy Organization journal · 2020Article
- IgE Epitope Profiling for Allergy Diagnosis and Therapy - Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform.Frontiers in immunology · 2020Article
- Microarray-Based Allergy Diagnosis: Quo Vadis?Frontiers in immunology · 2020Review
- Article
- Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgGThe Journal of allergy and clinical immunology · 2018Article
- Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence.EBioMedicine · 2017Article
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13 authors.
Funding
Abstract
backgroundAllergic sensitization is frequently present in asthma and rhinitis, but the role of specific immunoglobulin E (s-IgE) is not always clear. Multiple s-IgE analyses may provide insight into this relationship, thus a microarray chip was developed within the EU-funded MeDALL project. The main objective was to evaluate the performance of the MeDALL-chip compared to ImmunoCAP and skin prick test (SPT) in detecting allergic sensitization in children and secondarily to investigate the association to asthma and allergic rhinitis.
methodsFrom the 'Environment and Childhood Asthma Study', 265 children were investigated at 10 and 16 yr of age with clinical examination, interview, SPT, ImmunoCAP, and the MeDALL-chip including 152 allergen components in the analysis.
resultsAllergic sensitization at 10 yr was more frequently detected using the MeDALL-chip (38.1%) compared to the ImmunoCAP (32.8%) (p = 0.034) and SPT (25.5%) (p < 0.001), but no significant difference was seen at 16 yr (MeDALL-chip 49.8%, ImmunoCAP 48.6%, SPT 45.8%). The MeDALL-chip did not differ significantly from the ImmunoCAP or SPT in terms of detecting allergic sensitization in subjects with rhinitis or asthma at 10 or 16 yr.
conclusionThe prevalence of allergic sensitization increased by all three diagnostic tests from 10 to 16 yr was similar by SPT and ImmunoCAP and significantly higher with the MeDALL-chip at 10 yr. All three tests were comparable for identification of allergic sensitization among children with current rhinitis or asthma.
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