Evidence map›Paper›PMID 25720386›Full record

ArticleDiabetes2015

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents.

Qibin Qi, Mary K Downer, Tuomas O Kilpeläinen, H Rob Taal, Sheila J Barton, Ioanna Ntalla, Marie Standl, Vesna Boraska, Ville Huikari, Jessica C Kiefte-de Jong and 32 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01605123 (Leipzig Artherobesity Childhood Cohort), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01605123 completednot on this map

Leipzig Artherobesity Childhood Cohort

TypeobservationalSponsorUniversity of LeipzigRan2007 to 2017Enrolled200ConditionsObesity
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  12. Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
  13. TheCurrent developments in nutrition · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 11 countries.

Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY Department of Nutrition, Harvard School of Public Health, Boston, MA qibin.qi@einstein.yu.edu nhlqi@channing.harvard.edu.
Mary K DownerDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Tuomas O KilpeläinenMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital and University of Cambridge, Cambridge, U.K. The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
H Rob TaalThe Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands.
Sheila J BartonMRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, U.K.
Ioanna NtallaDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece Department of Health Sciences, University of Leicester, Leicester, U.K.
Marie StandlInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Vesna BoraskaWellcome Trust Sanger Institute, Hixton, Cambridge, U.K. Department of Medical Biology, University of Split School of Medicine, Split, Croatia.
Ville HuikariInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Jessica C Kiefte-de JongDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands Global Public Health, Leiden University College, Hague, the Netherlands.
Antje KörnerPediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany.
Timo A LakkaInstitute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Gaifen LiuDepartment of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, People's Republic of China.
Jessica MagnussonInstitute of Environmental Medicine, Karolinska Institutet, and Sachs' Children and Youth Hospital, Stockholm, Sweden.
Masayuki OkudaGraduate School of Science and Engineering, Yamaguchi University, Ube, Japan.
Olli RaitakariThe Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Rebecca RichmondMRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital and University of Cambridge, Cambridge, U.K.
Mark E S BaileySchool of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Kathrin ScheuermannPediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany.
John W HollowayHuman Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, U.K.
Hazel InskipMRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, U.K.
Carmen R IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Yasmin Mossavar-RahmaniDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Vincent W V JaddoeThe Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands.
Jaana LaitinenFinnish Institute of Occupational Health, Oulu, Finland.
Virpi LindiInstitute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, and Sachs' Children and Youth Hospital, Stockholm, Sweden.
Yannis PitsiladisSchool of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.
Niina PitkänenThe Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Georgia Prevention Center, Department of Pediatrics, Georgia Regents University, Augusta, GA.
Joachim HeinrichInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.
Tao WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Hinoda YujiHokkaido Nursing College, Chuo-ku, Sapporo, Japan.
Eleftheria ZegginiWellcome Trust Sanger Institute, Hixton, Cambridge, U.K.
George V DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Judith Wylie-RosettDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Ruth J F LoosMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital and University of Cambridge, Cambridge, U.K. The Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY.
Frank B HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA Department of Epidemiology, Harvard School of Public Health, Boston, MA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA qibin.qi@einstein.yu.edu nhlqi@channing.harvard.edu.
Albert Einstein College of Medicine · USErasmus MC · NLHarvard University · USHarokopio University of Athens · GRHelmholtz Zentrum München · DELeipzig University · DEUniversity of Bristol · GBUniversity of Eastern Finland · FIBeijing Tian Tan Hospital · CNChild Health and Development Institute · USFinnish Institute of Occupational Health · FIJapanese Red Cross Hokkaido College of Nursing · JPKarolinska Institutet · SENovo Nordisk Foundation · DKSachs' Children and Youth Hospital · SETurku University Hospital · FIUniversity Medical Center Groningen · NLUniversity of Oulu · FIUniversity of Split · HRUniversity of Turku · FI

Funding

APEX: ADIPOSITY PREVENTION BY EXERCISE IN BLACK GIRLSR01HL064972 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI BARBEAU, PAULE · 2000 to 2004
$3.5M
LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHSR01HL064157 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GUTIN, BERNARD · 2000 to 2003
$2.6M
British Heart Foundation RG/07/009/23120Medical Research Council MC_PC_15018Medical Research Council MC_U106179471Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/3Medical Research Council MC_UU_12015/1NHLBI NIH HHS HL64157NHLBI NIH HHS R01 HL064157NHLBI NIH HHS R01 HL064972Wellcome Trust 098051Wellcome Trust 102215
6 · The paper itself

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1-18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10(-4)), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10(-4)): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10(-10)) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

Indexed as

AdiposityEnergy IntakePolymorphism, Single NucleotideAdolescentAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexChildChild, PreschoolCross-Sectional StudiesDietary ProteinsFemaleHumansInfantMaleProteinsAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary ProteinsFTO protein, humanProteins

Identifiers

PMID25720386
PMCPMC4876751
OpenAlexW2161071800

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.