Trial reportClinical research in cardiology : official journal of the German Cardiac Society2015
Intraaortic balloon counterpulsation and microcirculation in cardiogenic shock complicating myocardial infarction: an IABP-SHOCK II substudy.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock.Scientific reports · 2024Trial
- Direct assessment of microcirculation in shock: a randomized-controlled multicenter study.Intensive care medicine · 2023Trial
- Intermittent Hypoxia Associated with Sleep Apnea Disrupts Microvascular Hemodynamics and Oxygen Delivery.Communications biology · 2026Article
- Cardiogenic shock syndrome unraveled: understanding the different layers of heterogeneity.Intensive care medicine · 2025Article
- Extending the 'host response' paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities.Critical care (London, England) · 2023Review
- Mottling as a prognosis marker in cardiogenic shock.Annals of intensive care · 2023Article
- Microcirculatory dysfunction in cardiogenic shock.Annals of intensive care · 2023Review
- Identifying a sublingual triangle as the ideal site for assessment of sublingual microcirculation.Journal of clinical monitoring and computing · 2023Article
- Toward a Broader Characterization of Macro- and Microcirculatory Uncoupling in Cardiogenic Shock.American journal of respiratory and critical care medicine · 2022Article
- Microcirculation in Patients with Takotsubo Syndrome-The Prospective CIRCUS-TTS Study.Journal of clinical medicine · 2021Article
- Lactate Clearance Predicts Good Neurological Outcomes in Cardiac Arrest Patients Treated with Extracorporeal Cardiopulmonary Resuscitation.Journal of clinical medicine · 2019Article
- Left ventricular unloading during veno-arterial ECMO: a review of percutaneous and surgical unloading interventions.Perfusion · 2019Review
- Vasopressors for acute myocardial infarction complicated by cardiogenic shock.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2019Review
- Prognostic relevance of serum lactate kinetics in critically ill patients.Intensive care medicine · 2019Article
- Left ventricular assist device therapy: the Kuwait experience.Journal of thoracic disease · 2018Article
- Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine.Intensive care medicine · 2018Article
- [Hypoxic hepatitis in cardiogenic shock : Incidence, laboratory detection and prognosis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Article
- Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Incidence, laboratory detection and prognostic relevance of hypoxic hepatitis in cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- IABP plus ECMO-Is one and one more than two?Journal of thoracic disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study sought to evaluate the influence of intraaortic balloon pump (IABP) counterpulsation on the microcirculation in patients with cardiogenic shock (CS) complicating acute myocardial infarction.
backgroundIn patients with shock profound alterations of the microcirculation have been observed and their clinical relevance has been described. Different treatment strategies exist to improve microvascular perfusion in patients with CS; however, the role of IABP treatment is not clearly defined.
methodsA predefined substudy of the randomized Intraaortic Balloon Pump in Cardiogenic Shock II trial (IABP-SHOCK II) investigated the sublingual microcirculation using a sidestream darkfield intravital microscope on days 1, 2 and 4 after the onset of shock. Perfused capillary (<20 µm, PCD) and vessel densities (<100 µm, PVD), total capillary (TCD) and vessel (TVD) densities were determined. In addition, the proportion of perfused vessels was assessed.
resultsForty-one patients were included in this substudy (n = 24 with IABP support vs. n = 17 without IABP support). No significant differences between treatment with or without IABP regarding PCD, PVD, TCD, TVD and the proportion of perfused vessels were evident on all three timepoints (p = n.s. for all). Microvascular perfusion showed inverse correlation with subsequent serum lactate levels (-0.366; p = 0.02) without being significantly correlated with lactate levels at the timepoint of the microcirculatory investigation. In Kaplan-Meier analysis microcirculatory parameters showed significant discrimination of prediction for time to death (p < 0.05 for all).
conclusionsIn patients with CS, there is no effect of IABP treatment on microvascular perfusion. Parameters of the microcirculation might be helpful to identify high risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.