Evidence map›Paper›PMID 25719969›Full record

ReviewReports on progress in physics. Physical Society (Great Britain)2015

Material properties of biofilms-a review of methods for understanding permeability and mechanics.

Nicole Billings, Alona Birjiniuk, Tahoura S Samad, Patrick S Doyle, Katharina Ribbeck

Abstract readReview
In one paragraph

Review in Reports on progress in physics. Physical Society (Great Britain), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Diversification of biofilm architecture among freshwaterApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Microorganisms · 2025
    Review
  10. Article
  11. Review
  12. Foods (Basel, Switzerland) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. A Hamilton principle-based model for diffusion-driven biofilm growth.Biomechanics and modeling in mechanobiology · 2024
    Article
  17. Review
  18. Article
  19. A laboratory perspective onFrontiers in microbiology · 2024
    Review
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole BillingsDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alona BirjiniukDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tahoura S SamadDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Patrick S DoyleDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WISHNOK, JOHN S. · 1985 to 2020
$25.6M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
Elucidation of structure and dynamics of bacterial biofilms by particle trackingF30AI110053 · NIAID · HARVARD MEDICAL SCHOOL · PI BIRJINIUK, ALONA · 2014 to 2017
$175k
NIAID NIH HHS 1F30AI110053-01NIAID NIH HHS F30 AI110053NIBIB NIH HHS R01 EB017755NIBIB NIH HHS R01EB017755NIEHS NIH HHS 5 T32 ES7020-37NIEHS NIH HHS P30 ES002109NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

Microorganisms can form biofilms, which are multicellular communities surrounded by a hydrated extracellular matrix of polymers. Central properties of the biofilm are governed by this extracellular matrix, which provides mechanical stability to the 3D biofilm structure, regulates the ability of the biofilm to adhere to surfaces, and determines the ability of the biofilm to adsorb gases, solutes, and foreign cells. Despite their critical relevance for understanding and eliminating of biofilms, the materials properties of the extracellular matrix are understudied. Here, we offer the reader a guide to current technologies that can be utilized to specifically assess the permeability and mechanical properties of the biofilm matrix and its interacting components. In particular, we highlight technological advances in instrumentation and interactions between multiple disciplines that have broadened the spectrum of methods available to conduct these studies. We review pioneering work that furthers our understanding of the material properties of biofilms.

Indexed as

BiofilmsMechanical PhenomenaPermeability

Identifiers

PMID25719969
PMCPMC4504244

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.