ArticleThe Journal of clinical endocrinology and metabolism2015
A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.
Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Reference Values for Biochemical Analytes in An Iranian Population: The Tehran Lipid and Glucose Study.International journal of endocrinology and metabolism · 2026Review
- Association between thyroid peroxidase antibodies and rheumatoid arthritis: insights from genetic and population-based evidence.Clinical rheumatology · 2026Article
- Thyroid hormones are associated with pituitary and thyroid volume in a population-based study.Journal of the Endocrine Society · 2026Article
- Thyroid peroxidase gene variants and autoimmunity in subclinical hypothyroidism: molecular mechanisms and clinical implications.Molecular biology reports · 2025Review
- P300 event-related potential in children with hypothyroidism.Journal of family medicine and primary care · 2025Article
- Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto's thyroiditis in a group of Iranian patients.Immunogenetics · 2024Article
- Toenail and blood selenium mediated regulation of thyroid dysfunction through immune cells: a mediation Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Epidemiology, Types, Causes, Clinical Presentation, Diagnosis, and Treatment of Hypothyroidism.Cureus · 2023Review
- Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization study in the European population.Frontiers in endocrinology · 2023Article
- Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study.Journal of geriatric cardiology : JGC · 2022Article
- The emerging role of exosomes in innate immunity, diagnosis and therapy.Frontiers in immunology · 2022Review
- Bidirectional Mendelian Randomization Analysis for Vitamin D and Thyroid Peroxidase Antibody.International journal of endocrinology · 2022Article
- Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2021Article
- Relationship between Gene Polymorphisms and Urine Iodine Levels on Susceptibility to Thyroid Peroxidase Antibody Positivity in the Chinese Population.European thyroid journal · 2021Article
- Influence of Rapid Urbanization on Thyroid Autoimmune Disease in China.International journal of endocrinology · 2021Article
- Hypothyroidism and Kidney Function: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2020Article
- Association Between Thyroid Dysfunction and Incident Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.Journal of endocrinology and metabolism · 2019Article
- Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.Thyroid : official journal of the American Thyroid Association · 2019Article
- Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.Scientific reports · 2019Article
- Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study.JAMA cardiology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
contextAntibodies against thyroid peroxidase (TPOAbs) are detected in 90% of all patients with Hashimoto thyroiditis, the most common cause of hypothyroidism. Hypothyroidism is associated with a range of adverse outcomes. The current knowledge of its genetic underpinnings is limited.
objectiveThe purpose of this study was to identify novel genetic variants associated with TPOAb concentrations and positivity using genome-wide association data and to characterize their association with thyroid function and disease. DESIGN, SETTING, AND
participantsWe studied European ancestry participants of 3 independent prospective population-based studies: Atherosclerosis Risk In Communities study (n = 7524), Study of Health in Pomerania (n = 3803), and Study of Health in Pomerania-TREND (n = 887). EXPOSURE: Single nucleotide polymorphisms (SNPs), individually and combined into a genetic risk score (GRS), were examined. MAIN OUTCOMES: The main outcomes were TPOAb concentrations and positivity, thyroid hormone concentrations (TSH, free T4), and clinical thyroid diseases (subclinical and overt hypothyroidism and goiter).
resultsSignificantly associated single nucleotide polymorphisms (P < 5 · 10(-8)) mapped into 4 genomic regions not previously implicated for TPOAbs (RERE, extended HLA region) and into 5 previously described loci. A higher Genetic Risk Score (GRS) based on these 9 SNPs showed strong and graded associations with higher TPOAb, TSH, and lower free T4 concentrations (P < .001). Compared with individuals in the lowest GRS quartile, those in the highest quartile had 1.80-fold higher odds of subclinical hypothyroidism (95% confidence interval, 1.27-2.55) and 1.89-fold higher odds of overt hypothyroidism (95% confidence interval, 1.24-2.87).
conclusionThe identification of 4 novel genetic loci associated with TPOAb concentrations and positivity gives further insight into the genetic underpinnings of hypothyroidism. A GRS showed strong and graded associations with markers of thyroid function and disease in independent population-based studies.
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