ReviewPLoS genetics2015
Closing the gap between knowledge and clinical application: challenges for genomic translation.
Review in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Molecular mastery: Harnessing DNA technology for disease prevention.Genes & diseases · 2026Review
- Opportunities and Challenges in Translating Genomics into Population Health Impact: Lessons from Familial Hypercholesterolemia.Public health genomics · 2026Review
- Lost in translation: why genomic breakthroughs are not reaching patients.BMJ oncology · 2026Article
- Biomarkers of Obsessive-Compulsive Disorder Subtypes: A Literature Review.International journal of molecular sciences · 2025Review
- The current landscape of personalised preventive approaches for non-communicable diseases: A scoping review.PloS one · 2025Article
- Effect of genetic profiling on surgical decisions at hereditary colorectal cancer syndromes.Heliyon · 2024Review
- Bridging the gap between omics research and dental practice.BDJ open · 2024Review
- Physicians' Perspectives on AI in Clinical Decision Support Systems: Interview Study of the CURATE.AI Personalized Dose Optimization Platform.JMIR human factors · 2023Article
- Determinants of targeted cancer therapy use in community oncology practice: a qualitative study using the Theoretical Domains Framework and Rummler-Brache process mapping.Implementation science communications · 2023Article
- Pharmacists' Knowledge, and Insights in Implementing Pharmacogenomics in Saudi Arabia.International journal of environmental research and public health · 2022Article
- Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series.Genome medicine · 2019Article
- Qualitative study of system-level factors related to genomic implementation.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- A logic model for precision medicine implementation informed by stakeholder views and implementation science.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Informing Integration of Genomic Medicine Into Primary Care: An Assessment of Current Practice, Attitudes, and Desired Resources.Frontiers in genetics · 2019Article
- Assessing risk for Mendelian disorders in a Bronx population.Molecular genetics & genomic medicine · 2017Article
- Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.BMC medical genomics · 2017Article
- Bermuda 2.0: reflections from Santa Cruz.GigaScience · 2016Article
- Ethical issues in pediatric genetic testing and screening.Current opinion in pediatrics · 2016Review
- Patient safety in genomic medicine: an exploratory study.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Genomic and clinical predictors for improving estimator precision in randomized trials of breast cancer treatments.Contemporary clinical trials communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite early predictions and rapid progress in research, the introduction of personal genomics into clinical practice has been slow. Several factors contribute to this translational gap between knowledge and clinical application. The evidence available to support genetic test use is often limited, and implementation of new testing programs can be challenging. In addition, the heterogeneity of genomic risk information points to the need for strategies to select and deliver the information most appropriate for particular clinical needs. Accomplishing these tasks also requires recognition that some expectations for personal genomics are unrealistic, notably expectations concerning the clinical utility of genomic risk assessment for common complex diseases. Efforts are needed to improve the body of evidence addressing clinical outcomes for genomics, apply implementation science to personal genomics, and develop realistic goals for genomic risk assessment. In addition, translational research should emphasize the broader benefits of genomic knowledge, including applications of genomic research that provide clinical benefit outside the context of personal genomic risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.