ArticleOncotarget2015
Ovariectomy shortens the life span of female mice.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
- Germ cells are hidden contributors to sex differences in vertebrate lifespan.The Journal of reproduction and development · 2026Review
- The ageing immune system as a driver of systemic ageing.Nature reviews. Immunology · 2026Review
- From germline immortality to somatic rejuvenation: Unlocking the ovarian blueprint for longevity.PLoS biology · 2026Article
- A preliminary investigation of gene expression and levels of FSH, IL-10, and TNF-α and histological staining in natural aging mice.Turkish journal of obstetrics and gynecology · 2026Article
- Sex differences in DNA methylation in bats.Annals of the New York Academy of Sciences · 2025Article
- A researcher's guide to studying sex differences in immune aging.Trends in molecular medicine · 2025Review
- Extracellular vesicles from cyclic mice modulate liver transcriptome in estroupause mice independent of age.Molecular and cellular endocrinology · 2025Article
- The androgen clock is an epigenetic predictor of long-term male hormone exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of cellular senescence in ovarian aging.npj aging · 2024Review
- The killifish germline regulates longevity and somatic repair in a sex-specific manner.Nature aging · 2024Article
- Ovarian tissue autotransplantation improves longevity in mice.Frontiers in physiology · 2024Article
- Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice.Aging cell · 2023Article
- Role of Estrogen Receptor α in Aging and Chronic Disease.Advances in geriatric medicine and research · 2023Article
- Cannabidiol Decreases Intestinal Inflammation in the Ovariectomized Murine Model of Postmenopause.Biomedicines · 2022Article
- Level of Estrogen in Females-The Different Impacts at Different Life Stages.Journal of personalized medicine · 2022Article
- Healthy Long-Lived Human Beings-Working on Life Stages to Break the Limitation of Human Lifespans.Biology · 2022Article
- Gene regulatory network inference in long-livediScience · 2022Article
- The Interrelationship Between Female Reproductive Aging and Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Review
- Sex Difference in Plasma Deoxyribonuclease Activity in Rats.Physiological research · 2021Article
- Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.Immunity · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA contents are increased in the liver, adipose tissue and aorta 7 months after ovariectomy (ovx) and this increased basal inflammation is maintained as the mice aged. In contrast, the extent of inflammatory gene expression is directly proportional to age in sham-operated mice. As a consequence, at 22 months, most of the inflammatory parameters examined were higher in the sham-operated group compared with the ovx group. These observations led us to propose that the decreased longevity of ovx mice may be due to an acceleration of the basal state of inflammation in metabolic organs, which is likely driven by the combination of a lack of estrogen-mediated anti-inflammatory activity and the loss of gonadal control of energy metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.