ArticlePloS one2015
Synergistic antimicrobial activity of Camellia sinensis and Juglans regia against multidrug-resistant bacteria.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 102 citations in OpenAlex.
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- The Antimicrobial Potential of the Hop (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Clinically relevant materials & applications inspired by food technologies.EBioMedicine · 2022Review
- Antimicrobial screening of polyherbal formulations traditionally used against gastrointestinal diseases.Saudi journal of biological sciences · 2021Article
- Antibacterial Activity of Medicinal Plants and Their Constituents in the Context of Skin and Wound Infections, Considering European Legislation and Folk Medicine-A Review.International journal of molecular sciences · 2021Review
- Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives.Microorganisms · 2021Review
- Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties.Antibiotics (Basel, Switzerland) · 2021Review
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- Antibacterial activity of plant species used for oral health against Porphyromonas gingivalis.PloS one · 2020Article
- Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics.AMB Express · 2019Article
- Current Challenges and Perspectives for the Use of Aqueous Plant Extracts in the Management of Bacterial Infections: The Case-Study ofInternational journal of molecular sciences · 2019Review
- Haplotype analysis of the germacrene A synthase gene and association with cynaropicrin content and biological activities in Cynara cardunculus.Molecular genetics and genomics : MGG · 2018Article
- Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases.BioMed research international · 2018Review
- Antiulcer Activity and Potential Mechanism of Action of the Leaves ofOxidative medicine and cellular longevity · 2018Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synergistic combinations of antimicrobial agents with different mechanisms of action have been introduced as more successful strategies to combat infections involving multidrug resistant (MDR) bacteria. In this study, we investigated synergistic antimicrobial activity of Camellia sinensis and Juglans regia which are commonly used plants with different antimicrobial agents. Antimicrobial susceptibility of 350 Gram-positive and Gram-negative strains belonging to 10 different bacterial species, was tested against Camellia sinensis and Juglans regia extracts. Minimum inhibitory concentrations (MICs) were determined by agar dilution and microbroth dilution assays. Plant extracts were tested for synergistic antimicrobial activity with different antimicrobial agents by checkerboard titration, Etest/agar incorporation assays, and time kill kinetics. Extract treated and untreated bacteria were subjected to transmission electron microscopy to see the effect on bacterial cell morphology. Camellia sinensis extract showed higher antibacterial activity against MDR S. Typhi, alone and in combination with nalidixic acid, than to susceptible isolates." We further explore anti-staphylococcal activity of Juglans regia that lead to the changes in bacterial cell morphology indicating the cell wall of Gram-positive bacteria as possible target of action. The synergistic combination of Juglans regia and oxacillin reverted oxacillin resistance of methicillin resistant Staphylococcus aureus (MRSA) strains in vitro. This study provides novel information about antimicrobial and synergistic activity of Camellia sinensis and Juglans regia against MDR pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.