ArticlePLoS genetics2015
An essential role of the arginine vasotocin system in mate-guarding behaviors in triadic relationships of medaka fish (Oryzias latipes).
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 96 citations in OpenAlex.
- Three-dimensional analysis of spawning behaviour of skipjack tuna Katsuwonus pelamis using stereo-image measurements.Biology open · 2026Article
- Structured spontaneous activity through delta oscillation-based discrete states in the medaka telencephalon.Scientific reports · 2026Article
- Article
- Temporal dynamics of courtship and spawning in medaka under laboratory conditions revealed by 24 h video monitoring.Scientific reports · 2025Article
- Measurement and classification of bold-shy behaviours in medaka fish.Bioinformatics (Oxford, England) · 2025Article
- Courtship and spawning behaviour of medaka in a semi-outdoor environment initiating at midnight.Scientific reports · 2025Article
- Mechanisms of social behaviour in the anti-social blind cavefish (Proceedings. Biological sciences · 2025Article
- Male medaka continue to mate with females despite sperm depletion.Royal Society open science · 2025Article
- Medaka (Oryzias latipes) initiate courtship and spawning late at night: Insights from field observations.PloS one · 2025Article
- An evolutionarily distinct Hmgn2 variant influences shape recognition in Medaka Fish.Communications biology · 2024Article
- The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept.Science advances · 2023Article
- Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish.Nature communications · 2023Article
- Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a2.Scientific reports · 2023Article
- Knock-out of vasotocin reduces reproductive success in female zebrafish,Frontiers in endocrinology · 2023Article
- Genetic dissection of steroid-hormone modulated social behavior: Novel paralogous genes are a boon for discovery.Hormones and behavior · 2023Review
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Review
- Reproductive roles of the vasopressin/oxytocin neuropeptide family in teleost fishes.Frontiers in endocrinology · 2022Review
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To increase individual male fitness, males of various species remain near a (potential) mating partner and repel their rivals (mate-guarding). Mate-guarding is assumed to be mediated by two different types of motivation: sexual motivation toward the opposite sex and competitive motivation toward the same sex. The genetic/molecular mechanisms underlying how mate presence affects male competitive motivation in a triadic relationship has remained largely unknown. Here we showed that male medaka fish prominently exhibit mate-guarding behavior. The presence of a female robustly triggers male-male competition for the female in a triadic relationship (2 males and 1 female). The male-male competition resulted in one male occupying a dominant position near the female while interfering with the other male's approach of the female. Paternity testing revealed that the dominant male had a significantly higher mating success rate than the other male in a triadic relationship. We next generated medaka mutants of arginine-vasotocin (avt) and its receptors (V1a1, V1a2) and revealed that two genes, avt and V1a2, are required for normal mate-guarding behavior. In addition, behavioral analysis of courtship behaviors in a dyadic relationship and aggressive behaviors within a male group revealed that avt mutant males displayed decreased sexual motivation but showed normal aggression. In contrast, heterozygote V1a2 mutant males displayed decreased aggression, but normal mate-guarding and courtship behavior. Thus, impaired mate-guarding in avt and V1a2 homozygote mutants may be due to the loss of sexual motivation toward the opposite sex, and not to the loss of competitive motivation toward rival males. The different behavioral phenotypes between avt, V1a2 heterozygote, and V1a2 homozygote mutants suggest that there are redundant systems to activate V1a2 and that endogenous ligands activating the receptor may differ according to the social context.
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