ArticleCambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees2015
Why is therapeutic misconception so prevalent?
Article in Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment.Journal of medical ethics · 2018Trial
- Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials.PloS one · 2017Trial
- Getting It "Right".Journal of empirical research on human research ethics : JERHRE · 2016Trial
- Therapeutic Misconception as a Problem of Nonmaleficence by Way of False Hope.Health care analysis : HCA : journal of health philosophy and policy · 2026Article
- Acceptability of blinded continuous glucose monitoring for people with serious mental illness and type 2 diabetes: findings from an exploratory mixed-methods study.Frontiers in clinical diabetes and healthcare · 2026Article
- Returning Individual-Level Urgent or Emergent Research Results to Participants: The Project Baseline Health Study Experience.American journal of medicine open · 2025Article
- Measuring the efficacy of community consultation in a pediatric exception from informed consent trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Article
- Revolutionizing Brain Research Using Portable MRI in Field Settings: Public Perspectives on the Ethical and Legal Challenges.Neuroethics · 2025Article
- Understanding the quality-of-life experiences of older or frail adults following a new dens fracture: Nonsurgical management in a hard collar versus early removal of collar.Health expectations : an international journal of public participation in health care and health policy · 2024Article
- Considerations for legal, ethical, and effective practice in dementia research.Brain communications · 2024Review
- Patient, Relative and Staff Experiences of Clinical Trial Participation in Neurooncology: "Maybe You Can Also Show the Positive, No Matter How It Ends".Cancer management and research · 2024Article
- Conceptual Framework for Smart Health: A Multi-Dimensional Model Using IPO Logic to Link Drivers and Outcomes.International journal of environmental research and public health · 2022Review
- YouTube as a source of information on breast cancer in the Arab world.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Ethical Development of Artificial Amniotic Sac and Placenta Technology: A Roadmap.Frontiers in pediatrics · 2021Article
- Non-maleficence and the ethics of consent to cancer screening.Journal of medical ethics · 2020Article
- Informed consent, therapeutic misconception, and clinical trials for Alzheimer's disease.International journal of geriatric psychiatry · 2020Article
- "Becoming myself": how participants in a longitudinal substance use disorder recovery study experienced receiving continuous feedback on their results.Substance abuse treatment, prevention, and policy · 2020Article
- Willingness of individuals with eating disorders to participate in health research.The International journal of eating disorders · 2019Article
- An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.Journal of clinical epidemiology · 2018Observational
- Minority Veterans Are More Willing to Participate in Complex Studies Compared to Non-minorities.Journal of bioethical inquiry · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Therapeutic misconception (TM)-when clinical research participants fail to adequately grasp the difference between participating in a clinical trial and receiving ordinary clinical care-has long been recognized as a significant problem in consent to clinical trials. We suggest that TM does not primarily reflect inadequate disclosure or participants' incompetence. Instead, TM arises from divergent primary cognitive frames. The researchers' frame places the clinical trial in the context of scientific designs for assessing intervention efficacy. In contrast, most participants have a cognitive frame that is personal and focused primarily on their medical problems. To illustrate this, we draw on interview material from both clinical researchers and participants in clinical trials. We suggest that reducing TM requires encouraging subjects to adjust their frame, not just add information to their existing frame. What is necessary is a scientific reframing of participation in a clinical trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.