ArticleeLife2015
Hox genes control vertebrate body elongation by collinear Wnt repression.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 144 citations in OpenAlex.
- Permissive and instructiveeLife · 2026Article
- Retention of embryonic positional identity signatures in the adult sheep tail: evidence from HOXB13 spatial RNA expression gradients.Scientific reports · 2026Article
- Genomic adaptations for tail-length evolution in arboreal snakes.Molecular biology and evolution · 2026Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- HOX and MEINOX in cellular plasticity, fibrosis, and cancer.World journal of stem cells · 2025Review
- Hoxb genes determine the timing of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation.Development (Cambridge, England) · 2025Article
- Extracellular volume expansion drives vertebrate axis elongation.Current biology : CB · 2025Article
- Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis.Frontiers in cell and developmental biology · 2025Article
- CTCF-dependent insulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cell density couples tissue mechanics to control the elongation speed of the body axis.iScience · 2024Article
- Article
- Heparan Sulfate Chain-Conjugated Laminin-E8 Fragments Advance Paraxial Mesodermal Differentiation Followed by High Myogenic Induction from hiPSCs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The Detection of a Functional 168 bp Deletion of theAnimals : an open access journal from MDPI · 2024Article
- Adaptive tail-length evolution in deer mice is associated with differential Hoxd13 expression in early development.Nature ecology & evolution · 2024Article
- CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.Biology open · 2024Article
- CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.bioRxiv : the preprint server for biology · 2024Article
- Article
- Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis.eLife · 2024Article
- Functional analysis of a first hindlimb positioning enhancer viaFrontiers in cell and developmental biology · 2024Article
- HOXA9 Regulome and Pharmacological Interventions in Leukemia.Advances in experimental medicine and biology · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
In vertebrates, the total number of vertebrae is precisely defined. Vertebrae derive from embryonic somites that are continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation. We show that in the chicken embryo, activation of posterior Hox genes (paralogs 9-13) in the tail-bud correlates with the slowing down of axis elongation. Our data indicate that a subset of progressively more posterior Hox genes, which are collinearly activated in vertebral precursors, repress Wnt activity with increasing strength. This leads to a graded repression of the Brachyury/T transcription factor, reducing mesoderm ingression and slowing down the elongation process. Due to the continuation of somite formation, this mechanism leads to the progressive reduction of PSM size. This ultimately brings the retinoic acid (RA)-producing segmented region in close vicinity to the tail bud, potentially accounting for the termination of segmentation and axis elongation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.