ReviewFrontiers in bioengineering and biotechnology2015
On the relative relevance of subject-specific geometries and degeneration-specific mechanical properties for the study of cell death in human intervertebral disk models.
Review in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Implant density reduction to avoid proximal junctional failure in adult spine surgery: Computer models and simulations.North American Spine Society journal · 2025Article
- A finite element study of the effect of cross-link stabilisation in a lumbar spine tumour model.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2025Article
- Parallel Networks to Predict TIMP and Protease Cell Activity of Nucleus Pulposus Cells Exposed and Not Exposed to Pro-Inflammatory Cytokines.JOR spine · 2025Article
- Influence of disc height and strain-dependent solute diffusivity on metabolic transport in patient-personalized intervertebral disc models.Frontiers in bioengineering and biotechnology · 2025Article
- Dataset of Finite Element Models of Normal and Deformed Thoracolumbar Spine.Scientific data · 2024Article
- Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- From MRI to FEM: an automated pipeline for biomechanical simulations of vertebrae and intervertebral discs.Frontiers in bioengineering and biotechnology · 2024Article
- Comparative FEM study on intervertebral disc modeling: Holzapfel-Gasser-Ogden vs. structural rebars.Frontiers in bioengineering and biotechnology · 2024Article
- Effects of geometric individualisation of a human spine model on load sharing: neuro-musculoskeletal simulation reveals significant differences in ligament and muscle contribution.Biomechanics and modeling in mechanobiology · 2023Article
- Patient-specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs.JOR spine · 2021Article
- Computational Challenges in Tissue Engineering for the Spine.Bioengineering (Basel, Switzerland) · 2021Review
- Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research.International journal of molecular sciences · 2021Review
- Patient-Specific Variations in Local Strain Patterns on the Surface of a Trussed Titanium Interbody Cage.Frontiers in bioengineering and biotechnology · 2021Article
- Intervertebral disc degeneration: an experimental and numerical study using a rabbit model.Medical & biological engineering & computing · 2018Article
- Lumbar model generator: a tool for the automated generation of a parametric scalable model of the lumbar spine.Journal of the Royal Society, Interface · 2018Article
- Theoretical Explorations Generate New Hypotheses About the Role of the Cartilage Endplate in Early Intervertebral Disk Degeneration.Frontiers in physiology · 2018Article
- Article
- Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.Royal Society open science · 2017Article
- Moderately degenerated lumbar motion segments: Are they truly unstable?Biomechanics and modeling in mechanobiology · 2017Article
- Intervertebral disc classification by its degree of degeneration from T2-weighted magnetic resonance images.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capturing patient- or condition-specific intervertebral disk (IVD) properties in finite element models is outmost important in order to explore how biomechanical and biophysical processes may interact in spine diseases. However, disk degenerative changes are often modeled through equations similar to those employed for healthy organs, which might not be valid. As for the simulated effects of degenerative changes, they likely depend on specific disk geometries. Accordingly, we explored the ability of continuum tissue models to simulate disk degenerative changes. We further used the results in order to assess the interplay between these simulated changes and particular IVD morphologies, in relation to disk cell nutrition, a potentially important factor in disk tissue regulation. A protocol to derive patient-specific computational models from clinical images was applied to different spine specimens. In vitro, IVD creep tests were used to optimize poro-hyperelastic input material parameters in these models, in function of the IVD degeneration grade. The use of condition-specific tissue model parameters in the specimen-specific geometrical models was validated against independent kinematic measurements in vitro. Then, models were coupled to a transport-cell viability model in order to assess the respective effects of tissue degeneration and disk geometry on cell viability. While classic disk poro-mechanical models failed in representing known degenerative changes, additional simulation of tissue damage allowed model validation and gave degeneration-dependent material properties related to osmotic pressure and water loss, and to increased fibrosis. Surprisingly, nutrition-induced cell death was independent of the grade-dependent material properties, but was favored by increased diffusion distances in large IVDs. Our results suggest that in situ geometrical screening of IVD morphology might help to anticipate particular mechanisms of disk degeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.