Evidence map›Paper›PMID 25717419›Full record

ArticleJournal of molecular biomarkers & diagnosis

YKL-40 is a Protective Biomarker for Fatty Liver in World Trade Center Particulate Matter-Exposed Firefighters.

Soo Jung Cho, Ghislaine C Echevarria, Young Im Lee, Sophia Kwon, Kwan Yong Park, Jun Tsukiji, William N Rom, David J Prezant, Anna Nolan, Michael D Weiden

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biomarkers & diagnosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanisms of Environmental Contributions to Fatty Liver Disease.Current environmental health reports · 2019
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Soo Jung ChoDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA.
Ghislaine C EchevarriaDivision of Anestesiology, School of Medicine, Pontifical Catholic University of Chile-Santiago, Chile ; Department of Anesthesiology, New York University School of Medicine, New York, USA.
Young Im LeeDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA.
Sophia KwonDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA.
Kwan Yong ParkDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA.
Jun TsukijiDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA.
William N RomDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA ; Department of Environmental Medicine, New York University, School of Medicine, NY, USA.
David J PrezantBureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY, USA ; Pulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Anna NolanDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA ; Department of Environmental Medicine, New York University, School of Medicine, NY, USA ; Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY, USA.
Michael D WeidenDivision of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New York, USA ; Department of Environmental Medicine, New York University, School of Medicine, NY, USA ; Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY, USA.
New York City Fire Department · US

Funding

CD80 and CD86 mediated innate immune response in sepsisK23HL084191 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2008 to 2013
$955k
NHLBI NIH HHS K23 HL084191
6 · The paper itself

Abstract

backgroundSerum biomarkers of metabolic syndrome predict abnormal lung function in World Trade Center particulate matter (WTC-PM)-exposed Fire Department of New York (FDNY) rescue workers. In animal models, exposure to ambient PM induces non-alcoholic fatty liver disease (NAFLD), a well-known comorbidity of metabolic syndrome. YKL-40 is an inflammatory biomarker for both liver and lung disease. We tested if YKL-40 is a biomarker for NAFLD in this dust-exposed cohort.

methodsUsing a nested case-control design, we studied 131 FDNY personnel who had Computer Tomography performed within 5 years post 9/11. NAFLD was defined by a liver/spleen attenuation ratio of ≤1. Serum biomarkers, lipid panel and liver function were measured in serum that had been drawn within 6 months of September 11, 2001. YKL-40 and chitotriosidase were assayed by ELISA. We tested biomarker and NAFLD association using logistic regression adjusted for age, BMI, and post-911 lung function.

resultsNAFLD was present in 29/131 (22%) of the cohort. In a multivariable model increasing YKL-40 was protective while increasing triglyceride and alkaline phosphatase were risk factors for NAFLD.

conclusionsIncreased YKL-40 is a protective biomarker in non-alcoholic fatty liver disease. Further studies may reveal a link between PM-induced lung and liver diseases.

Indexed as

BiomarkerNon-alcoholic fatty liver diseaseYKL-40

Identifiers

PMID25717419
PMCPMC4337810
OpenAlexW2099209787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.