Evidence map›Paper›PMID 25717414›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2014

Automated physician order recommendations and outcome predictions by data-mining electronic medical records.

Jonathan H Chen, Russ B Altman

Abstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. An atomic approach to the design and implementation of a research data warehouse.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
  2. Integrating Clinical Knowledge and Real-World Evidence for Type 2 Diabetes Treatment.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019
    Article
  3. Article
  4. Article
  5. Inpatient Clinical Order Patterns Machine-Learned From Teaching Versus Attending-Only Medical Services.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018
    Article
  6. Article
  7. Predicting inpatient clinical order patterns with probabilistic topic models vs conventional order sets.Journal of the American Medical Informatics Association : JAMIA · 2017
    Article
  8. Therapy Decision Support Based on Recommender System Methods.Journal of healthcare engineering · 2017
    Article
  9. Article
  10. Article
  11. DYNAMICALLY EVOLVING CLINICAL PRACTICES AND IMPLICATIONS FOR PREDICTING MEDICAL DECISIONS.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2016
    Article
  12. Data-Mining Electronic Medical Records for Clinical Order Recommendations: Wisdom of the Crowd or Tyranny of the Mob?AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2015
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan H ChenDepartment of Medicine, Stanford University, Stanford, CA 94305, USA.
Russ B AltmanDepartment of Medicine, Stanford University, Stanford, CA 94305, USA. ; Departments of Bioengineering and Genetics, Stanford University, Stanford, CA 94305, USA.

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Text Mining for High-fidelity Curation and Discovery of Gene-drug-phenotype RelationshipsR01LM005652 · NLM · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2000 to 2018
$6.2M
Undergraduate Summer Research Experiences Support for Combining systems biology and structural biology to find new therapeuticsR01GM102365 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2012 to 2021
$3.0M
NCATS NIH HHS UL1 TR001085NCRR NIH HHS UL1 RR025744NIGMS NIH HHS R01 GM102365NIGMS NIH HHS R24 GM061374NLM NIH HHS R01 LM005652
6 · The paper itself

Abstract

The meaningful use of electronic medical records (EMR) will come from effective clinical decision support (CDS) applied to physician orders, the concrete manifestation of clinical decision making. CDS development is currently limited by a top-down approach, requiring manual production and limited end-user awareness. A statistical data-mining alternative automatically extracts expertise as association statistics from structured EMR data (>5.4M data elements from >19K inpatient encounters). This powers an order recommendation system analogous to commercial systems (e.g., Amazon.com's "Customers who bought this…"). Compared to a standard benchmark, the association method improves order prediction precision from 26% to 37% (p<0.01). Introducing an inverse frequency weighted recall metric demonstrates a quantifiable improvement from 3% to 17% (p<0.01) in recommending more specifically relevant orders. The system also predicts clinical outcomes, such as 30 day mortality and 1 week ICU intervention, with ROC AUC of 0.88 and 0.78 respectively, comparable to state-of-the-art prognosis scores.

Identifiers

PMID25717414
PMCPMC4333710

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.