ArticleWorld journal of cardiology2015
Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature.
Article in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Differentiating Ischemic From Nonischemic T-Wave Inversion Using a Multimodal Vision-Language Model With Reinforcement Learning (ECG-R1): Development and Validation Study.JMIR medical informatics · 2026Article
- Takotsubo T Waves---a Diagnostically Useful Electrocardiographic Pattern in 10 Case Presentations.CJC open · 2025Article
- Troponin May Lie: Recognizing an Atypical Case of Wellens Syndrome.Clinical case reports · 2025Article
- Surfing the T Wave: A Primer on ECG T Wave Morphologies Encountered in Clinical Trials and Impact on the QT Interval and Patient Safety.Clinical and translational science · 2025Review
- Observational
- Longitudinal ECG changes among adults with HIV in Tanzania: A prospective cohort study.PLOS global public health · 2023Article
- Brazilian Society of Cardiology Guidelines on the Analysis and Issuance of Electrocardiographic Reports - 2022.Arquivos brasileiros de cardiologia · 2022Article
- Remote Analysis and Transmission System of Electrocardiogram in Prehospital Setting; a Diagnostic Accuracy Study.Archives of academic emergency medicine · 2022Article
- An idiopathic case of precordial deep T-wave inversion.Annals of medicine and surgery (2012) · 2021Article
- When Manual Analysis of 12-Lead ECG Holter Plays a Critical Role in Discovering Unknown Patterns of Increased Arrhythmogenic Risk: A Case Report of a Patient Treated with Tamoxifen and Subsequent Pneumonia in COVID-19.Cardiovascular toxicology · 2021Article
- Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?Journal of the American Heart Association · 2021Article
- Article
- Late T-wave inversion following resolution of non-ischemic acute pulmonary edema.Clinical case reports · 2019Article
- Article
- T-Wave Abnormality as Electrocardiographic Signature of Myocardial Edema in Non-ST-Elevation Acute Coronary Syndromes.Journal of the American Heart Association · 2018Article
- Neutropenia and T-Wave Inversion as Toxin-Mediated Complications of a Streptococcal Infection.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2017Article
- Magnetocardiographic evaluation of nonarrhythmogenic flecainide-induced electrocardiographic T-wave inversion.Anatolian journal of cardiology · 2017Article
- ELECTROCARDIOGRAM CHANGES IN ADDISON DISEASE: POTENTIAL CLINICAL MARKER FOR ADRENAL CRISIS.AACE clinical case reportsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe the electrocardiographic (ECG) phenomena characterized by T-wave inversion in the precordial leads in adults and to highlight its differential diagnosis.
methodsA retrospective chart review of 8 adult patients who were admitted with ECG T-wave inversion in the anterior chest leads with or without prolongation of corrected QT (QTc) interval. They had different clinical conditions. Each patient underwent appropriate clinical assessment including investigation for myocardial involvement. Single and multimodality non-invasive, semi-invasive and invasive diagnostic approach were used to ascertain the diagnosis. The diagnostic assessment included biochemical investigation, cardiac and abdominal ultrasound, cerebral and chest computed tomography, nuclear medicine and coronary angiography.
resultsEight adult subjects (5 females) with a mean age of 66 years (range 51 to 82) are analyzed. The etiology of T-wave inversion in the precordial leads were diverse. On admission, all patients had normal blood pressure and the ECG showed sinus rhythm. Five patients showed marked prolongation of the QTc interval. The longest QTc interval (639 ms) was found in the patient with pheochromocytoma. Giant T-wave inversion (≥ 10 mm) was found in pheochromocytoma followed by electroconvulsive therapy and finally ischemic heart disease. The deepest T-wave was measured in lead V3 (5 ×). In 3 patients presented with mild T-wave inversion (patients 1, 5 and 4 mm), the QTc interval was not prolonged (432, 409 and 424 msec), respectively.
conclusionT-wave inversion associated with or without QTc prolongation requires meticulous history taking, physical examination and tailored diagnostic modalities to reach rapid and correct diagnosis to establish appropriate therapeutic intervention.
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