ArticleDiabetology & metabolic syndrome2015
Association of chronic diabetes and hypertension in sural nerve morphometry: an experimental study.
Article in Diabetology & metabolic syndrome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study.Frontiers in endocrinology · 2022Trial
- Development and validation of a nomogram for diabetic tibial neuropathy based on ultrasound radiomics: a multicenter study.BMC medical imaging · 2025Article
- Hypertension is associated with the reduction in epidermal small fibres independently of sural nerve inflammation in type 2 diabetic subjects.Journal of neurochemistry · 2025Article
- Development and validation of a risk prediction model for painful diabetic peripheral neuropathy in type 2 diabetes mellitus: a multicenter retrospective study.Frontiers in endocrinology · 2025Article
- Anethole Prevents the Alterations Produced by Diabetes Mellitus in the Sciatic Nerve of Rats.International journal of molecular sciences · 2024Article
- Sympathetic skin response for early detection of type 2 diabetic peripheral neuropathy and nephropathy.Journal of diabetes investigation · 2024Article
- Superimposition of hypertension on diabetic peripheral neuropathy affects small unmyelinated sensory nerves in the skin and myelinated tibial and sural nerves in rats with alloxan-induced type 1 diabetes.Journal of toxicologic pathology · 2020Article
- Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy.International journal of nephrology · 2020Article
- Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes.American journal of hypertension · 2019Article
- Alternatives to the Streptozotocin-Diabetic Rodent.International review of neurobiology · 2016Review
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Authors and funding
8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundProspective studies have shown incidence rates of hypertension in diabetes mellitus to be three times that of subjects without diabetes mellitus. The reverse also applies, with the incidence of diabetes two to three times higher in patients with hypertension. Despite this common clinical association, the contribution of each isolated entity in the development of a neuropathy is still not well understood. The aims of the present study were to investigate the presence of peripheral neuropathy in spontaneously hypertensive rats (SHR) and SHR with chronically induced diabetes, using a morphological and morphometric study of the sural nerves.
methodsFemale SHR and normotensive Wistar rats (WR), 8 weeks old, received a single intravenous injection of streptozotocin (STZ) through the tail vein. Controls from both strains received vehicle. Twelve weeks after the injection, sural nerves were dissected and prepared for light microscopy. Morphometry of sural nerve fascicles and myelinated fibers was performed with the aid of computer software.
resultsThe sural nerve myelinated fibers were highly affected by experimental diabetes in normotensive rats, causing mainly the reduction of the fiber size. Hypertensive rats showed characteristics of small fiber neuropathy and a severe reduction of the number and density or Schwann cells. The association between diabetes and hypertension caused an increase on the average size of the myelinated fibers, pointing to a small fiber loss, associated to axonal atrophy.
conclusionsOur study gives morphological support to the existence of a neuropathy due to hypertension, which is among one of the most common risk factors for diabetic neuropathy. The association between the two neuropathies showed to be a complex alteration, involving and including both, large and small fibers neuropathy. Hypertension caused, indeed, an exacerbation of the alterations already observed in experimental models of diabetic neuropathy.
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