Evidence map›Paper›PMID 25717264›Full record

ArticleWorld journal of gastroenterology2015

Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation.

Yong-Zhen Kang, Xiao-Ye Sun, Yi-He Liu, Zhong-Yang Shen

Open access · hybridAbstract readCase Reports
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yong-Zhen KangYong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
Xiao-Ye SunYong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
Yi-He LiuYong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
Zhong-Yang ShenYong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
Tianjin First Center Hospital · CN

Funding

NIAAA NIH HHS N01 AA021001
6 · The paper itself

Abstract

Although the development of de novo autoimmune liver disease after liver transplantation (LT) has been described in both children and adults, autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome has rarely been seen in liver transplant recipients. Here, we report a 50-year-old man who underwent LT for decompensated liver disease secondary to alcoholic steatohepatitis. His liver function tests became markedly abnormal 8 years after LT. Standard autoimmune serological tests were positive for anti-nuclear and anti-mitochondrial antibodies, and a marked biochemical response was observed to a regimen consisting of prednisone and ursodeoxycholic acid added to maintain immunosuppressant tacrolimus. Liver biopsy showed moderate bile duct lesions and periportal lymphocytes infiltrating along with light fibrosis, which confirmed the diagnosis of AIH-PBC overlap syndrome. We believe that this may be a case of post-LT de novo AIH-PBC overlap syndrome; a novel type of autoimmune overlap syndrome.

Indexed as

Cholagogues and CholereticsCholestasisFatty Liver, AlcoholicHepatitis, AutoimmuneHumansImmunosuppressive AgentsLiver Cirrhosis, BiliaryLiver Function TestsLiver TransplantationMaleMiddle AgedPrednisoneTacrolimusTreatment OutcomeUrsodeoxycholic AcidCholagogues and CholereticsImmunosuppressive AgentsPrednisoneTacrolimusUrsodeoxycholic AcidAutoimmune hepatitisAutoimmune liver diseaseBiliary strictureLiver transplantationOverlap syndromePrimary biliary cirrhosis

Identifiers

PMID25717264
PMCPMC4326166
OpenAlexW174974708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.