Evidence map›Paper›PMID 25717239›Full record

ArticleWorld journal of gastroenterology2015

Increased inspiratory esophagogastric junction pressure in systemic sclerosis: an add-on to antireflux barrier.

Miguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Armênio Aguiar dos Santos

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Lower esophageal sphincter pressure measurement under standardized inspiratory maneuveurs.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Miguel Ângelo Nobre e SouzaMiguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil.
Patrícia Carvalho BezerraMiguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil.
Rivianny Arrais NobreMiguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil.
Esther Studart da Fonseca HolandaMiguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil.
Armênio Aguiar dos SantosMiguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil.
Instituto Federal de Educação, Ciência e Tecnologia do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate crural diaphragm (CD) function in systemic sclerosis (SSc) using high-resolution manometry and standardized inspiratory maneuvers.

methodsEight SSc volunteers (average age, 40.1 years; one male) and 13 controls (average age, 32.2 years; six males) participated in the study. A high-resolution manometry/impedance system measured the esophagus and esophagogastric junction (EGJ) pressure profile during swallows and two respiratory maneuvers: sinus arrhythmia maneuver (SAM; the average of six EGJ peak pressures during 5-s deep inhalations) and threshold maneuver (TM; the EGJ peak pressures during forced inhalation under 12 and 24 cmH2O loads). Inspiratory diaphragm lowering (IDL) was taken as the displacement of the EGJ high-pressure zone during the SAM.

resultsSSc patients had lower mean lower esophageal sphincter pressure than controls during normal breathing (19.7±2.8 mmHg vs 32.2±2.7 mmHg, P=0.007). Sinus arrhythmia maneuver pressure was higher in SSc patients than in controls (142.6±9.4 mmHg vs 104.6±13.8 mmHg, P=0.019). Sinus arrhythmia maneuver pressure normalized to IDL was also higher in SSc patients than in controls (83.8±13.4 mmHg vs 37.5±6.9 mmHg, P=0.005). Threshold maneuver pressures normalized to IDL were also greater in SSc patients than in controls (TM 12 cmH2O: 85.1±16.4 mmHg vs 43.9±6.3 mmHg, P=0.039; TM 24 cmH2O: 85.2±16.4 mmHg vs 46.2±6.6 mmHg, P=0.065). Inspiratory diaphragm lowering in SSc patients was less than in controls (2.1±0.3 cm vs 3±0.2 cm, P=0.011).

conclusionSSc patients had increased inspiratory EGJ pressure. This is an add-on to EGJ pressure and indicates that the antireflux barrier can be trained.

Indexed as

InhalationAdultBreathing ExercisesCase-Control StudiesDeglutitionDiaphragmEsophageal Motility DisordersEsophageal Sphincter, LowerEsophagogastric JunctionFemaleGastroesophageal RefluxHumansMaleManometryPressureScleroderma, SystemicCrural diaphragmGastroesophageal refluxLower esophageal sphincterSystemic sclerosis

Identifiers

PMID25717239
PMCPMC4326141
OpenAlexW39334085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.