ArticleJournal of neurophysiology2015
Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Structured connectivity in the output of the cerebellar cortex.Nature communications · 2024Article
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Activity of Cerebellar Nuclei Neurons Correlates with ZebrinII Identity of Their Purkinje Cell Afferents.Cells · 2021Article
- Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.Brain pathology (Zurich, Switzerland) · 2021Article
- AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.Cell reports · 2020Article
- Purkinje Cell-Specific Knockout of Tyrosine Hydroxylase Impairs Cognitive Behaviors.Frontiers in cellular neuroscience · 2020Article
- Article
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.PLoS computational biology · 2019Article
- Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours.eLife · 2019Article
- Depressed by Learning-Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells.Cerebellum (London, England) · 2018Review
- Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].Cerebellum (London, England) · 2018Review
- Computational Principles of Supervised Learning in the Cerebellum.Annual review of neuroscience · 2018Review
- Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations.The Journal of physiology · 2017Article
- Synaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites.Frontiers in cellular neuroscience · 2017Article
- Heterogeneity of Matrin 3 in the developing and aging murine central nervous system.The Journal of comparative neurology · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The massive computational capacity of the cerebellar cortex is conveyed by Purkinje cells onto cerebellar and vestibular nuclei neurons through their GABAergic, inhibitory output. This implies that pauses in Purkinje cell simple spike activity are potentially instrumental in cerebellar information processing, but their occurrence and extent are still heavily debated. The cerebellar cortex, although often treated as such, is not homogeneous. Cerebellar modules with distinct anatomical connectivity and gene expression have been described, and Purkinje cells in these modules also differ in firing rate of simple and complex spikes. In this study we systematically correlate, in awake mice, the pausing in simple spike activity of Purkinje cells recorded throughout the entire cerebellum, with their location in terms of lobule, transverse zone, and zebrin-identified cerebellar module. A subset of Purkinje cells displayed long (>500-ms) pauses, but we found that their occurrence correlated with tissue damage and lower temperature. In contrast to long pauses, short pauses (<500 ms) and the shape of the interspike interval (ISI) distributions can differ between Purkinje cells of different lobules and cerebellar modules. In fact, the ISI distributions can differ both between and within populations of Purkinje cells with the same zebrin identity, and these differences are at least in part caused by differential synaptic inputs. Our results suggest that long pauses are rare but that there are differences related to shorter intersimple spike intervals between and within specific subsets of Purkinje cells, indicating a potential further segregation in the activity of cerebellar Purkinje cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.