ArticleJournal of neurophysiology2015
Lempel-Ziv complexity of cortical activity during sleep and waking in rats.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- The Caffeinated Brain Part 2: The Effect of Caffeine on Sleep-Related Electroencephalography (EEG)-A Systematic and Mechanistic Review.Nutrients · 2026Pooled it
- Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Intermittent tACS during a visual task impacts neural oscillations and LZW complexity.Experimental brain research · 2020Trial
- The entropic brain today.Brain : a journal of neurology · 2026Review
- Impact of Recording Conditions and Feature Fusion on Dementia Classification Using Spectral, Entropy, and Complexity EEG Features.Entropy (Basel, Switzerland) · 2026Article
- Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats.Methods and protocols · 2026Article
- Electrophysiological effects of psilocybin co-administered with midazolam.Translational psychiatry · 2026Article
- On the meaning of "plasticity" in neuroscience and mental health research and its relation to the action of psychedelic therapy.Frontiers in neuroscience · 2026Article
- Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats.Advanced pharmaceutical bulletin · 2025Article
- Mental Fatigue Detection of Crane Operators Based on Electroencephalogram Signals Acquired by a Novel Rotary Switch-Type Semi-Dry Electrode Using Multifractal Detrend Fluctuation Analysis.Sensors (Basel, Switzerland) · 2025Article
- Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.Neuroscience · 2025Article
- Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation.Frontiers in neural circuits · 2025Article
- Beyond-local neural information processing in neuronal networks.Computational and structural biotechnology journal · 2024Article
- A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior.Nature neuroscience · 2024Article
- Linear mixed-effect models for correlated response to process electroencephalogram recordings.Cognitive neurodynamics · 2024Article
- Spectral Slope and Lempel-Ziv Complexity as Robust Markers of Brain States during Sleep and Wakefulness.eNeuro · 2024Article
- Sleep restores an optimal computational regime in cortical networks.Nature neuroscience · 2024Article
- Exploring effects of anesthesia on complexity, differentiation, and integrated information in rat EEG.Neuroscience of consciousness · 2024Article
- The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle.Neurochemical research · 2023Article
- Decreased aperiodic neural activity in Parkinson's disease and dementia with Lewy bodies.Journal of neurology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Understanding the dynamics of brain activity manifested in the EEG, local field potentials (LFP), and neuronal spiking is essential for explaining their underlying mechanisms and physiological significance. Much has been learned about sleep regulation using conventional EEG power spectrum, coherence, and period-amplitude analyses, which focus primarily on frequency and amplitude characteristics of the signals and on their spatio-temporal synchronicity. However, little is known about the effects of ongoing brain state or preceding sleep-wake history on the nonlinear dynamics of brain activity. Recent advances in developing novel mathematical approaches for investigating temporal structure of brain activity based on such measures, as Lempel-Ziv complexity (LZC) can provide insights that go beyond those obtained with conventional techniques of signal analysis. Here, we used extensive data sets obtained in spontaneously awake and sleeping adult male laboratory rats, as well as during and after sleep deprivation, to perform a detailed analysis of cortical LFP and neuronal activity with LZC approach. We found that activated brain states-waking and rapid eye movement (REM) sleep are characterized by higher LZC compared with non-rapid eye movement (NREM) sleep. Notably, LZC values derived from the LFP were especially low during early NREM sleep after sleep deprivation and toward the middle of individual NREM sleep episodes. We conclude that LZC is an important and yet largely unexplored measure with a high potential for investigating neurophysiological mechanisms of brain activity in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.