Evidence map›Paper›PMID 25717145›Full record

ReviewJournal of leukocyte biology2015

Neutrophils in host defense: new insights from zebrafish.

Elizabeth A Harvie, Anna Huttenlocher

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 126 citations in OpenAlex.

  1. Article
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  11. Article
  12. Zebrafish (International journal of molecular sciences · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Infection of endemic chubParasitology · 2024
    Article
  18. Review
  19. leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
  20. Differential Expression Genes of the Head Kidney and Spleen inInternational journal of molecular sciences · 2023
    Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elizabeth A Harvie*Microbiology Doctoral Training Program, Departments of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Anna Huttenlocher*Microbiology Doctoral Training Program, Departments of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA huttenlocher@wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

Neutrophil Chemotaxis in AutoinflammationR01GM074827 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HUTTENLOCHER, ANNA · 2005 to 2015
$3.3M
NIGMS NIH HHS R01 GM074827
6 · The paper itself

Abstract

Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.

Indexed as

Immunity, InnateAnimalsAnimals, Genetically ModifiedDisease Models, AnimalInfectionsNeutrophilsZebrafishinfectioninnate immunity

Identifiers

PMID25717145
PMCPMC4569048
OpenAlexW2125246793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.