ArticleJournal of radiation research2015
Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation.
Article in Journal of radiation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Multinomial probability model of radiation induced DSB and non-DSB clusters: tandem and bistranded damage clusters.Scientific reports · 2026Article
- High-complexity of DNA double-strand breaks is key for alternative end-joining choice.Communications biology · 2024Article
- Comparison of mutation spectra induced by gamma-rays and carbon ion beams.Journal of radiation research · 2024Article
- Exploring the Effect of High-Energy Heavy Ion Beam on Rice Genome: Transposon Activation.Genes · 2023Article
- Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- DNA strand break induction of aqueous plasmid DNA exposed to 30 MeV protons at ultra-high dose rate.Journal of radiation research · 2022Article
- Article
- Oxidation resistance 1 functions in the maintenance of cellular survival and genome stability in response to oxidative stress-independent DNA damage.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- A Simplified Cluster Analysis of Electron Track Structure for Estimating Complex DNA Damage Yields.International journal of molecular sciences · 2020Article
- Reproductive hazards of space travel in women and men.Nature reviews. Endocrinology · 2019Review
- The Influence of (5'Cells · 2019Article
- Clustered DNA Damages induced by 0.5 to 30 eV Electrons.International journal of molecular sciences · 2019Review
- Effect of transcutaneous electrical acupoint stimulation on protecting against radiotherapy- induced ovarian damage in mice.Journal of ovarian research · 2019Article
- Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors.Radiation research · 2018Article
- An ion beam-induced Arabidopsis mutant with marked chromosomal rearrangement.Journal of radiation research · 2017Article
- Very low doses of heavy oxygen ion radiation induce premature ovarian failure.Reproduction (Cambridge, England) · 2017Article
- Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes.Nucleic acids research · 2017Article
- Identification of Substitutions and Small Insertion-Deletions Induced by Carbon-Ion Beam Irradiation inFrontiers in plant science · 2017Article
- Charged iron particles, components of space radiation, destroy ovarian follicles.Human reproduction (Oxford, England) · 2016Article
- Investigation of X-ray permeability of surgical gloves coated with different contrast agents.Anatolian journal of cardiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us to investigate the importance of clustered DNA damage in the biological effects of heavy ion beam radiation. In this study, we analyzed the yield of clustered base damage (comprising multiple base lesions) in cultured cells irradiated with various heavy ion beams, and investigated isolated base damage and the repair process in post-irradiation cultured cells. Chinese hamster ovary (CHO) cells were irradiated by carbon, silicon, argon and iron ion beams with LETs of 13, 55, 90 and 200 keV µm(-1), respectively. Agarose gel electrophoresis of the cells with enzymatic treatments indicated that clustered base damage yields decreased as the LET increased. The aldehyde reactive probe procedure showed that isolated base damage yields in the irradiated cells followed the same pattern. To analyze the cellular base damage process, clustered DNA damage repair was investigated using DNA repair mutant cells. DNA double-strand breaks accumulated in CHO mutant cells lacking Xrcc1 after irradiation, and the cell viability decreased. On the other hand, mouse embryonic fibroblast (Mef) cells lacking both Nth1 and Ogg1 became more resistant than the wild type Mef. Thus, clustered base damage seems to be involved in the expression of heavy ion beam biological effects via the repair process.
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