ArticleCirculation. Heart failure2015
Activities of daily living and outcomes in heart failure.
Article in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 5 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Digital Health Technology for Improving Physical Function in Adults With Chronic Heart Failure: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Heart Failure in Patients with Sarcopenia: Systematic Review and Meta-Analysis.Annals of geriatric medicine and research · 2025Pooled it
- The Metabolic Vulnerability Index: A Novel Marker for Mortality Prediction in Heart Failure.JACC. Heart failure · 2024Pooled it
- The Prevalence of Activities of Daily Living Impairment in Patients With Heart Failure: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021Pooled it
- Bridging the post-hospitalization gap: a feasibility study of home-based rehabilitation in decompensated heart failure.ESC heart failure · 2026Trial
- Clinical Impact of Hospital-Associated Disability in Patients With Acute Decompensated Heart Failure.Circulation reports · 2026Article
- Machine Learning Models Incorporating Nursing Care Needs to Predict 180-Day Prognosis in Patients With Heart Failure: Validation With Discrimination and Calibration Analyses.Circulation reports · 2026Article
- Life-Space Mobility in Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure - intersections · 2026Article
- Combined strength and aerobic training vs. aerobic training alone in patients with heart failure: A systematic review and meta-analysis.Journal of sport and health science · 2026Review
- Social isolation, loneliness, disability progression, and mortality among older adults with cardiac disease: a longitudinal NHATS study.Frontiers in psychiatry · 2026Article
- Dressing-induced hemodynamic instability in patients with heart failure: Implications for nursing care.PloS one · 2026Observational
- Development and Validation of a Prognostic Model for One-year Mortality in Older Adults with Acute Myocardial Infarction Incorporating Activities of Daily Living Impairment.Clinical interventions in aging · 2026Article
- A Multicohort Machine Learning Framework to Predict Mortality in Elderly Patients With Heart Disease: Insights From HARLS, SHARE, and HRS.Cardiovascular therapeutics · 2026Article
- Occupational Performance and Quality of Life in Individuals With Cardiovascular Conditions: A Cross-Sectional Study.Occupational therapy international · 2026Article
- Nutritional risk, frailty and functional status in elderly heart failure patients.ESC heart failure · 2025Article
- Prognostic Impact of Hospitalization-Associated Disability and Care Level in Older Heart Failure Patients - Findings From the J-Proof HF Registry.Circulation reports · 2025Article
- Investigating the correlation of self-care and quality-of-life patients with heart failure.BMC cardiovascular disorders · 2025Article
- Oxygen supplementation in ambulatory patients with heart failure: a randomized proof-of-concept study.European heart journal open · 2025Article
- Cardiorespiratory fitness in stroke patients with different activities of daily living levels: a cross-sectional study.Scientific reports · 2025Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic disease can contribute to functional disability, which can degrade quality of life. However, the prevalence of functional disability and its association with outcomes among patients with heart failure requires further study. METHODS AND
resultsSoutheastern Minnesota residents with heart failure were enrolled from September 2003 through January 2012 into a cohort study with follow-up through December 2012. Difficulty with 9 activities of daily living (ADLs) was assessed by a questionnaire. Patients were divided into 3 categories of ADL difficulty (no/minimal, moderate, severe). The associations of ADL difficulty with mortality and hospitalization were assessed using Cox and Andersen-Gill models. Among 1128 patients (mean age, 74.7 years; 49.2% female), a majority (59.4%) reported difficulty with one or more ADLs at enrollment, with 272 (24.1%) and 146 (12.9%) experiencing moderate and severe difficulty, respectively. After a mean (SD) follow-up of 3.2 (2.4) years, 614 patients (54.4%) had died. Mortality increased with increasing ADL difficulty; the hazard ratio (95% confidence interval) for death was 1.49 (1.22-1.82) and 2.26 (1.79-2.86) for those with moderate and severe difficulty, respectively, compared to those with no/minimal difficulty (Ptrend<0.001). Patients with moderate and severe difficulty were at an increased risk for all-cause and noncardiovascular hospitalization. In a second assessment, 17.7% of survivors reported more difficulty with ADLs and patients with persistently severe or worsening difficulty were at an increased risk for death (hazard ratio, 2.10; 95% confidence interval, 1.71-2.58; P<0.001) and hospitalization (hazard ratio, 1.51; 95% confidence interval, 1.31-1.74; P<0.001).
conclusionsFunctional disability is common in patients with heart failure, can progress over time, and is associated with adverse prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.