ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015
Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- Soy isoflavones decrease fibroglandular breast tissue measured by magnetic resonance imaging in premenopausal women: A 2-year randomized double-blind placebo controlled clinical trial.Clinical nutrition ESPEN · 2022Trial
- The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study.Breast cancer research : BCR · 2018Trial
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment.Cell communication and signaling : CCS · 2026Article
- Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index.Breast cancer research : BCR · 2025Article
- Studying the association between longitudinal nondense breast tissue measurements and the risk of breast cancer: a joint modeling approach.American journal of epidemiology · 2025Article
- Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Nature communications · 2024Article
- The Associations between Intakes of One-Carbon Metabolism-Related Vitamins and Breast Density among Young Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- The mediating role of mammographic density in the protective effect of early-life adiposity on breast cancer risk: a multivariable Mendelian randomization study.medRxiv : the preprint server for health sciences · 2023Article
- Protein Ligands in the Secretome of CD36Cancers · 2021Article
- Cancer Progress and Priorities: Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.Breast cancer research and treatment · 2021Article
- Screening Algorithms in Dense Breasts:AJR. American journal of roentgenology · 2021Review
- Quantitative Mammographic Density Measurements and Molecular Subtypes in Chinese Women With Breast Cancer.JNCI cancer spectrum · 2021Article
- Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study.International journal of cancer · 2021Article
- Breast health screening: a UK-wide questionnaire.BMJ nutrition, prevention & health · 2021Article
- Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer.Breast cancer research : BCR · 2019Article
- Amount of fibroglandular tissue FGT and background parenchymal enhancement BPE in relation to breast cancer risk and false positives in a breast MRI screening program : A retrospective cohort study.European radiology · 2019Article
- Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy.Breast cancer research : BCR · 2019Article
- Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.Breast cancer research : BCR · 2019Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundMammographic density (MD) is a strong breast cancer risk factor. We previously reported associations of percent mammographic density (PMD) with larger and node-positive tumors across all ages, and estrogen receptor (ER)-negative status among women ages <55 years. To provide insight into these associations, we examined the components of PMD [dense area (DA) and nondense area (NDA)] with breast cancer subtypes.
methodsData were pooled from six studies including 4,095 breast cancers and 8,558 controls. DA and NDA were assessed from digitized film-screen mammograms and standardized across studies. Breast cancer odds by density phenotypes and age according to histopathologic characteristics and receptor status were calculated using polytomous logistic regression.
resultsDA was associated with increased breast cancer risk [OR for quartiles: 0.65, 1.00 (Ref), 1.22, 1.55; P(trend) <0.001] and NDA was associated with decreased risk [ORs for quartiles: 1.39, 1.00 (Ref), 0.88, 0.72; P(trend) <0.001] across all ages and invasive tumor characteristics. There were significant trends in the magnitude of associations of both DA and NDA with breast cancer by increasing tumor size (P(trend) < 0.001) but no differences by nodal status. Among women <55 years, DA was more strongly associated with increased risk of ER(+) versus ER(-) tumors (P(het) = 0.02), while NDA was more strongly associated with decreased risk of ER(-) versus ER(+) tumors (P(het) = 0.03).
conclusionsDA and NDA have differential associations with ER(+) versus ER(-) tumors that vary by age. IMPACT: DA and NDA are important to consider when developing age- and subtype-specific risk models.
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