Evidence map›Paper›PMID 25716940›Full record

ArticleEuropean radiology2015

Wavelet-based calculation of cerebral angiographic data from time-resolved CT perfusion acquisitions.

Lukas Havla, Kolja M Thierfelder, Sebastian E Beyer, Wieland H Sommer, Olaf Dietrich

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Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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3 · Its place in the literature

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5 citing papers in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Lukas HavlaJosef-Lissner-Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistr. 15, 81377, Munich, Germany, lukas.havla@med.uni-muenchen.de.
Kolja M Thierfelder
Sebastian E Beyer
Wieland H Sommer
Olaf Dietrich

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate a new approach for reconstructing angiographic images by application of wavelet transforms on CT perfusion data.

methodsFifteen consecutive patients with suspected stroke were examined with a multi-detector CT acquiring 32 dynamic phases (∆t = 1.5s) of 99 slices (total slab thickness 99mm) at 80kV/200mAs. Thirty-five mL of iomeprol-350 was injected (flow rate = 4.5mL/s). Angiographic datasets were calculated after initial rigid-body motion correction using (a) temporally filtered maximum intensity projections (tMIP) and (b) the wavelet transform (Paul wavelet, order 1) of each voxel time course. The maximum of the wavelet-power-spectrum was defined as the angiographic signal intensity. The contrast-to-noise ratio (CNR) of 18 different vessel segments was quantified and two blinded readers rated the images qualitatively using 5pt Likert scales.

resultsThe CNR for the wavelet angiography (501.8 ± 433.0) was significantly higher than for the tMIP approach (55.7 ± 29.7, Wilcoxon test p < 0.00001). Image quality was rated to be significantly higher (p < 0.001) for the wavelet angiography with median scores of 4/4 (reader 1/reader 2) than the tMIP (scores of 3/3).

conclusionsThe proposed calculation approach for angiography data using temporal wavelet transforms of intracranial CT perfusion datasets provides higher vascular contrast and intrinsic removal of non-enhancing structures such as bone. KEY POINTS: • Angiographic images calculated with the proposed wavelet-based approach show significantly improved contrast-to-noise ratio. • CT perfusion-based wavelet angiography is an alternative method for vessel visualization. • Provides intrinsic removal of non-enhancing structures such as bone.

Indexed as

AdolescentAdultAgedAged, 80 and overCerebral AngiographyContrast MediaFemaleHumansImage Processing, Computer-AssistedIopamidolMaleMiddle AgedMultidetector Computed TomographyRadiographic Image EnhancementStrokeYoung AdultContrast MediaiomeprolIopamidol

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.