ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Prenatal Stress Alters the Development of Socioemotional Behavior and Amygdala Neuron Excitability in Rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Maternal depression and offspring neurodevelopmental impairments in wild rodents induced by ecologically relevant prenatal stress.Molecular psychiatry · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.Journal of neuroendocrinology · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis.Brain, behavior, & immunity - health · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways.Journal of psychiatric research · 2025Article
- Assessment of Prenatal Transportation Stress and Sex on Gene Expression Within the Amygdala of Brahman Calves.Biology · 2024Article
- The Relevance of Animal Models of Social Isolation and Social Motivation for Understanding Schizophrenia: Review and Future Directions.Schizophrenia bulletin · 2023Review
- Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.The Journal of nutritional biochemistry · 2023Article
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- From circuits to behavior: Amygdala dysfunction in fragile X syndrome.Frontiers in integrative neuroscience · 2023Review
- Prenatal Relocation Stress Enhances Resilience Under Challenge in Infant Rhesus Macaques.Frontiers in behavioral neuroscience · 2021Article
- Prenatal Stress Leads to the Altered Maturation of Corticostriatal Synaptic Plasticity and Related Behavioral Impairments Through Epigenetic Modifications of Dopamine D2 Receptor in Mice.Molecular neurobiology · 2021Article
- Becoming Stressed: Does the Age Matter? Reviewing the Neurobiological and Socio-Affective Effects of Stress throughout the Lifespan.International journal of molecular sciences · 2020Review
- The children of Superstorm Sandy: Maternal prenatal depression blunts offspring electrodermal activity.Biological psychology · 2019Article
- Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats.Scientific reports · 2019Article
- Mast Cells, Stress, Fear and Autism Spectrum Disorder.International journal of molecular sciences · 2019Review
- Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring.Behavioural brain research · 2019Article
- Infant Temperament: Repercussions of Superstorm Sandy-Related Maternal Stress.Child psychiatry and human development · 2019Article
- Elevated intracellular NaJournal of neurochemistry · 2017Article
- Prenatal stressors in rodents: Effects on behavior.Neurobiology of stress · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prenatal stress (PS) is a risk factor for neurodevelopmental disorders with diverse ages of onset and socioemotional symptoms. Some PS-linked disorders involve characteristic social deficits, such as autism spectrum disorders and schizophrenia, but PS also promotes anxiety disorders. We propose the diversity of symptoms following PS arises from perturbations to early brain development. To this end, we characterized the effects of PS on the developmental trajectory of physiology of the amygdala, a late-developing center for socioemotional control. We found that PS dampened socioemotional behavior and reduced amygdala neuron excitability in offspring during infancy (at postnatal days (P)10, 14, 17 and 21), preadolescence (day 28), and adulthood (day 60). PS offspring in infancy produced fewer isolation-induced vocalizations and in adulthood exhibited less anxiety-like behavior and deficits in social interaction. PS neurons had a more hyperpolarized resting membrane potential from infancy to adulthood and produced fewer action potentials. Moreover, adult amygdala neurons from PS animals expressed larger action potential afterhyperpolarizations and H-current relative to controls, further limiting excitability. Our results suggest that PS can suppress socioemotional behavior throughout development and produce age-specific alterations to amygdala physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.