ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Divisive gain modulation of motoneurons by inhibition optimizes muscular control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Probabilistic inference of homonymous and heteronymous recurrent inhibition in human muscles from large-scale motor neuron recordings.Science advances · 2026Article
- V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inhibition for gain modulation in the motor system.Experimental brain research · 2022Review
- Acquisition of novel ball-related skills associated with sports experience.Scientific reports · 2021Article
- Why Firing Rate Distributions Are Important for Understanding Spinal Central Pattern Generators.Frontiers in human neuroscience · 2021Article
- Article
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- Gain control in the sensorimotor system.Current opinion in physiology · 2019Article
- A muscle-activity-dependent gain between motor cortex and EMG.Journal of neurophysiology · 2019Article
- Commentary: Synaptic Excitation in Spinal Motoneurons Alternates with Synaptic Inhibition and Is Balanced by Outward Rectification during Rhythmic Motor Network Activity.Frontiers in neural circuits · 2018Article
- Spike threshold dynamics in spinal motoneurons during scratching and swimming.The Journal of physiology · 2017Article
- Spinal Cord Preparation from Adult Red-eared Turtles for Electrophysiological Recordings during Motor Activity.Bio-protocol · 2017Article
- Intense Activity of the Raphe Spinal Pathway Depresses Motor Activity via a Serotonin Dependent Mechanism.Frontiers in neural circuits · 2017Article
- Neuronal Population Activity in Spinal Motor Circuits: Greater Than the Sum of Its Parts.Frontiers in neural circuits · 2017Review
- Shared Components of Rhythm Generation for Locomotion and Scratching Exist Prior to Motoneurons.Frontiers in neural circuits · 2017Article
- Estimation of Synaptic Conductances in Presence of Nonlinear Effects Caused by Subthreshold Ionic Currents.Frontiers in computational neuroscience · 2017Article
- Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.eLife · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When using muscles, the precision with which force is delivered is as important as the delivery of force itself. Force is regulated by both the number of recruited motoneurons and their spike frequency. While it is known that the recruitment is ordered to reduce variability in force, it remains unclear whether the motoneuron gain, i.e., the slope of the transformation between synaptic input and spiking output, is also modulated to reduce variability in force. To address this issue, we use turtle hindlimb scratching as a model for fine motor control, since this behavior involves precise limb movement to rub the location of somatic nuisance touch. We recorded intracellularly from motoneurons in a reduced preparation where the limbs were removed to increase mechanical stability and the motor nerve activity served as a surrogate for muscle force. We found that not only is the gain of motoneurons regulated on a subsecond timescale, it is also adjusted to minimize variability. The modulation is likely achieved via an expansive nonlinearity between spike rate and membrane potential with inhibition having a divisive influence. These findings reveal a versatile mechanism of modulating neuronal sensitivity and suggest that such modulation is fundamentally linked to optimization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.