ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Electrophysiological Characterization of Murine Vestibular Efferent Neurons and Modulation by Acute Peripheral Vestibular Deprivation.Neuroscience bulletin · 2026Article
- Neurotransmitter regulatory networks in persistent postural-perceptual dizziness: potential mechanisms and therapeutic implications.Frontiers in neurology · 2026Review
- Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Simultaneous Dual Recordings From Vestibular Hair Cells and Their Calyx Afferents Demonstrate Multiple Modes of Transmission at These Specialized Endings.Frontiers in neurology · 2022Review
- The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents.Scientific reports · 2021Article
- Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery.Neuroscience · 2021Article
- Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear.Frontiers in neuroscience · 2021Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
- Calretinin Immunoreactivity in the VIIIth Nerve and Inner Ear Endorgans ofFrontiers in neuroscience · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Efferent synaptic transmission at the vestibular type II hair cell synapse.Journal of neurophysiology · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
- Efferent Inputs Are Required for Normal Function of Vestibular Nerve Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle.Frontiers in cellular neuroscience · 2019Article
- Sensory Hair Cells: An Introduction to Structure and Physiology.Integrative and comparative biology · 2018Review
- ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.Journal of neurophysiology · 2018Article
- Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance.Frontiers in molecular neuroscience · 2018Article
- Effect of M-current modulation on mammalian vestibular responses to transient head motion.Journal of neurophysiology · 2017Article
- Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways.Journal of audiology & otology · 2017Review
- Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.Journal of neurophysiology · 2017Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Electrical stimulation of vestibular efferent neurons rapidly excites the resting discharge of calyx/dimorphic (CD) afferents. In turtle, this excitation arises when acetylcholine (ACh), released from efferent terminals, directly depolarizes calyceal endings by activating nicotinic ACh receptors (nAChRs). Although molecular biological data from the peripheral vestibular system implicate most of the known nAChR subunits, specific information about those contributing to efferent-mediated excitation of CD afferents is lacking. We sought to identify the nAChR subunits that underlie the rapid excitation of CD afferents and whether they differ from α9α10 nAChRs on type II hair cells that drive efferent-mediated inhibition in adjacent bouton afferents. We recorded from CD and bouton afferents innervating the turtle posterior crista during electrical stimulation of vestibular efferents while applying several subtype-selective nAChR agonists and antagonists. The α9α10 nAChR antagonists, α-bungarotoxin and α-conotoxin RgIA, blocked efferent-mediated inhibition in bouton afferents while leaving efferent-mediated excitation in CD units largely intact. Conversely, 5-iodo-A-85380, sazetidine-A, varenicline, α-conotoxin MII, and bPiDDB (N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide) blocked efferent-mediated excitation in CD afferents without affecting efferent-mediated inhibition in bouton afferents. This pharmacological profile suggested that calyceal nAChRs contain α6 and β2, but not α9, nAChR subunits. Selective blockade of efferent-mediated excitation in CD afferents distinguished dimorphic from calyx afferents by revealing type II hair cell input. Dimorphic afferents differed in having higher mean discharge rates and a mean efferent-mediated excitation that was smaller in amplitude yet longer in duration. Molecular biological data demonstrated the expression of α9 in turtle hair cells and α4 and β2 in associated vestibular ganglia.
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