ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Hippocampome.org v2.0: a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits.bioRxiv : the preprint server for biology · 2024Article
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- Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits.Molecular psychiatry · 2023Review
- Individual/Peak Gamma Frequency: What Do We Know?Brain sciences · 2023Review
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models.International journal of molecular sciences · 2022Review
- Optogenetics: implications for Alzheimer's disease research and therapy.Molecular brain · 2022Review
- Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden inFrontiers in synaptic neuroscience · 2022Article
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Parvalbumin and Somatostatin Interneurons Contribute to the Generation of Hippocampal Gamma Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The critical role of persistent sodium current in hippocampal gamma oscillations.Neuropharmacology · 2020Article
- Comparison of three gamma oscillations in the mouse entorhinal-hippocampal system.The European journal of neuroscience · 2018Article
- In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick.The European journal of neuroscience · 2018Article
- Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice.Journal of visualized experiments : JoVE · 2018Article
- NMDA-receptor inhibition and oxidative stress during hippocampal maturation differentially alter parvalbumin expression and gamma-band activity.Scientific reports · 2018Article
- A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.eLife · 2018Article
- Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus.Nature communications · 2017Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells.Nature communications · 2017Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Information processing in neuronal networks relies on the precise synchronization of ensembles of neurons, coordinated by the diverse family of inhibitory interneurons. Cortical interneurons can be usefully parsed by embryonic origin, with the vast majority arising from either the caudal or medial ganglionic eminences (CGE and MGE). Here, we examine the activity of hippocampal interneurons during gamma oscillations in mouse CA1, using an in vitro model where brief epochs of rhythmic activity were evoked by local application of kainate. We found that this CA1 KA-evoked gamma oscillation was faster than that in CA3 and, crucially, did not appear to require the involvement of fast-spiking basket cells. In contrast to CA3, we also found that optogenetic inhibition of pyramidal cells in CA1 did not significantly affect the power of the oscillation, suggesting that excitation may not be essential for gamma genesis in this region. We found that MGE-derived interneurons were generally more active than CGE interneurons during CA1 gamma, although a group of CGE-derived interneurons, putative trilaminar cells, were strongly phase-locked with gamma oscillations and, together with MGE-derived axo-axonic and bistratified cells, provide attractive candidates for being the driver of this locally generated, predominantly interneuron-driven model of gamma oscillations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.