Evidence map›Paper›PMID 25716777›Full record

Trial reportThe international journal of neuropsychopharmacology2015

A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment.

Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Chun-Hsien Chu, Shih-Heng Chen, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Treatment Strategies for the Opioid-Dependent Patient.Current pain and headache reports · 2017
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sheng-Yu LeeDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Shiou-Lan ChenDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Yun-Hsuan ChangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Chun-Hsien ChuDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Shih-Heng ChenDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Po See ChenDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
San-Yuan HuangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Nian-Sheng TzengDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Liang-Jen WangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
I Hui LeeDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Tzu-Yun WangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Kao Chin ChenDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Yen Kuang YangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Jau-Shyong HongDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu).
Ru-Band LuDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (Dr S-Y Lee); Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan (Drs S-Y Lee, P Chen, I Lee, T-Y Wang, K Chen, Yang, and Lu); Department of Neurology, School of medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (Dr S-L Chen); Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan (Drs Chang and Lu); Laboratory of Neurobiology, NIH/NIEHS, Research Triangle Park, NC (Drs Chu and S-H Chen); Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Drs Huang and Tzeng); Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan (Drs L-J Wang, T-Y Wang, and Hong); Institute of Behavioral Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Addiction Research Center, National Cheng Kung University, Tainan, Taiwan (Dr Lu); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan (Dr Lu). rblu@mail.ncku.edu.tw.

Funding

Roles Of Brain Neuroimmune System In NeurodegenerationZIAES090082 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HONG, JAU-SHYONG SHYONG · 2009 to 2018
$22.0M
6 · The paper itself

Abstract

backgroundLow-dose dextromethorphan (DM) might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. In a randomized, double-blind, controlled 12 week study, we investigated whether add-on dextromethorphan reduced cytokine levels and benefitted opioid-dependent patients undergoing methadone maintenance therapy (MMT).

methodsPatients were randomly assigned to a group: DM60 (60mg/day dextromethorphan; n = 65), DM120 (120mg/day dextromethorphan; n = 65), or placebo (n = 66). Primary outcomes were the methadone dose required, plasma morphine level, and retention in treatment. Plasma tumor necrosis factor (TNF)-α, C-reactive protein, interleukin (IL)-6, IL-8, transforming growth factor-β1, and brain-derived neurotrophic factor (BDNF) levels were examined during weeks 0, 1, 4, 8, and 12. Multiple linear regressions with generalized estimating equation methods were used to examine the therapeutic effect.

resultsAfter 12 weeks, the DM60 group had significantly longer treatment retention and lower plasma morphine levels than did the placebo group. Plasma TNF-α was significantly decreased in the DM60 group compared to the placebo group. However, changes in plasma cytokine levels, BDNF levels, and the methadone dose required in the three groups were not significantly different.

conclusionsWe provide evidence-decreased concomitant heroin use-of low-dose add-on DM's efficacy for treating opioid-dependent patients undergoing MMT.

Indexed as

AdultAnalgesics, OpioidBrain-Derived Neurotrophic FactorC-Reactive ProteinDextromethorphanDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationExcitatory Amino Acid AntagonistsFemaleHumansInterleukin-6Interleukin-8MaleMethadoneMiddle AgedAnalgesics, OpioidBrain-Derived Neurotrophic FactorC-Reactive ProteinDextromethorphanExcitatory Amino Acid AntagonistsIL6 protein, humanInterleukin-6Interleukin-8MethadoneMorphineTNF protein, humanTransforming Growth Factor beta1Tumor Necrosis Factor-alphacytokineCytokinesdextromethorphanDextromethorphanHeroinmethadone maintenance therapyopioid dependence

Identifiers

PMID25716777
PMCPMC4540107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.