ArticleHypertension research : official journal of the Japanese Society of Hypertension2015
Aortic stiffness is associated with the central retinal arteriolar equivalent and retinal vascular fractal dimension in a population along the southeastern coast of China.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Retinal Arteriovenous Information Improves the Prediction Accuracy of Deep Learning-Based baPWV Index From Color Fundus Photographs.Investigative ophthalmology & visual science · 2025Article
- Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning.International journal of ophthalmology · 2024Article
- The role of retinal vessel geometry as an indicator of systemic arterial stiffness assessed by cardio-ankle vascular index.Frontiers in cardiovascular medicine · 2023Article
- Carotid stiffness is associated with retinal microvascular dysfunction-The Maastricht study.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Association between retinal arterial narrowing and left ventricular diastolic dysfunction in masked hypertensives.Journal of clinical hypertension (Greenwich, Conn.) · 2020Observational
- Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population.Hypertension (Dallas, Tex. : 1979) · 2019Article
- A high-salt diet enhances leukocyte adhesion in association with kidney injury in young Dahl salt-sensitive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Retinal microvascular diameter, a hypertension-related trait, in ECG-gated vs. non-gated images analyzed by IVAN and SIVA.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Retinal vessel caliber and its relationship with nocturnal blood pressure dipping status: the SABPA study.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Relationships between retinal arteriole anatomy and aortic geometry and function and peripheral resistance in hypertensives.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Association of body composition and blood pressure categories with retinal vessel diameters in primary school children.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Article
- Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging.BMC cardiovascular disorders · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the association of the central retinal arteriolar equivalent (CRAE) and the retinal vascular fractal dimension, two quantitative parameters that reflect microcirculation, with aortic stiffness. In this cross-sectional study, we identified the cardiovascular risk factors in 2169 subjects using a health questionnaire, physical examinations and laboratory examinations. We evaluated the aortic stiffness using noninvasive brachial-ankle pulse wave velocity (baPWV) and assessed the microcirculatory alterations with CRAE and retinal vascular fractal dimension, which were measured using fundus photography and semiautomatic quantitative software, respectively. The increase in baPWV (Q1-Q4) correlated with an increased likelihood of the central retinal artery narrowing and a reduction in the retinal vascular fractal dimension. Further adjustment of the cardiovascular risk factors diminished the association between baPWV and CRAE, but increased the association between baPWV and retinal vascular fractal dimension. Elevated baPWV correlates with reduced CRAE and retinal vascular fractal dimension. Such a finding supports macrocirculation- and microcirculation-associated hypotheses.
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