ArticleThe Journal of nutrition2015
Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans.
Article in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Vitamin Metabolism and Its Dependency on Genetic Variations Among Healthy Adults: A Systematic Review for Precision Nutrition Strategies.Nutrients · 2025Pooled it
- Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes-A Narrative Review of the Case of Vitamins.Frontiers in nutrition · 2020Pooled it
- Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude.European journal of nutrition · 2019Trial
- The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.Frontiers in immunology · 2025Article
- Review
- Role of rs2282679 in 25-hydroxyvitamin D levels and insulin resistance after a sleeve gastrectomy.Nutrition & diabetes · 2024Article
- Vitamin D and risk of hypertension among Black women.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Article
- A Comparison Study of Vitamin D Deficiency among Older Adults in China and the United States.Scientific reports · 2019Article
- Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole-exome next generation sequencing.Brain and behavior · 2019Article
- Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women.Infectious diseases in obstetrics and gynecology · 2019Article
- Glutathione Stimulates Vitamin D Regulatory and Glucose-Metabolism Genes, Lowers Oxidative Stress and Inflammation, and Increases 25-Hydroxy-Vitamin D Levels in Blood: A Novel Approach to Treat 25-Hydroxyvitamin D Deficiency.Antioxidants & redox signaling · 2018Article
- Familial clustering of vitamin D deficiency via shared environment: The Korean National Health and Nutrition Examination Survey 2008-2012.European journal of clinical nutrition · 2018Article
- Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011⁻2012.Nutrients · 2018Article
- Function of the vitamin D endocrine system in mammary gland and breast cancer.Molecular and cellular endocrinology · 2017Review
- Investigating nutrition and lifestyle factors as determinants of abdominal obesity: an environment-wide study.International journal of obesity (2005) · 2017Article
- Predicted 25-hydroxyvitamin D in relation to incidence of breast cancer in a large cohort of African American women.Breast cancer research : BCR · 2016Article
- Article
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundLow circulating 25-hydroxyvitamin D [25(OH)D] is prevalent in African Americans, but predictors of vitamin D status are understudied compared to Caucasian populations.
objectiveWe investigated whether certain environmental and genetic factors are predictors of circulating 25(OH)D in 989 elderly African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study.
methodsRegression analysis estimated the cross-sectional association of nongenetic (environmental) factors with 25(OH)D. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D in Caucasian genome-wide association studies (GWASs) were analyzed for association with serum 25(OH)D, including analyses of all imputed SNPs in identified genomic regions. Genome-wide complex trait analysis (GCTA) evaluated the association of all (genome-wide) genotyped SNPs with serum 25(OH)D in the Health ABC Study with replication in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
resultsGender, study site, season of blood draw, body mass index, dietary supplement use, dairy and cereal consumption, Healthy Eating Index score, and walking >180 min/wk were associated with 25(OH)D (P < 0.05), jointly explaining 25% of the variation in circulating 25(OH)D. Multivitamin supplement use was the strongest predictor of circulating 25(OH)D, and supplement users had a 6.3-μg/L higher serum 25(OH)D concentration compared with nonusers. Previous GWAS-identified gene regions were not replicated in African Americans, but the nonsynonymous rs7041 SNP in group-specific component (vitamin D binding protein) was close to significance thresholds (P = 0.08), and there was evidence for an interaction between this SNP and use of multivitamin supplements in relation to serum 25(OH)D concentration (P = 0.04). Twenty-three percent (95% CI: 0%, 52%) of the variation in serum 25(OH)D was explained by total genetic variation in a pooled GCTA of 2087 Health ABC Study and MESA African-American participants, but population substructure effects could not be separated from other genetic influences.
conclusionsModifiable dietary and lifestyle predictors of serum 25(OH)D were identified in African Americans. GCTA confirms that a proportion of 25(OH)D variability is attributable to genetic variation, but genomic regions associated with the 25(OH)D phenotype identified in prior GWASs of European Americans were not replicated in the Health ABC Study in African Americans.
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