SynthesisJournal of anesthesia2015
Effects of volatile vs. propofol-based intravenous anesthetics on the alveolar inflammatory responses to one-lung ventilation: a meta-analysis of randomized controlled trials.
Synthesis in Journal of anesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pooled it
- Desflurane improves lung collapse more than propofol during one-lung ventilation and reduces operation time in lobectomy by video-assisted thoracic surgery: a randomized controlled trial.BMC anesthesiology · 2022Trial
- Usefulness of combining clinical and biochemical parameters for prediction of postoperative pulmonary complications after lung resection surgery.Journal of clinical monitoring and computing · 2019Trial
- The effects of one-lung ventilation mode on lung function in elderly patients undergoing esophageal cancer surgery.Medicine · 2018Trial
- Lung protective characteristics of volatile anesthetic sedation.Critical care (London, England) · 2026Review
- Multidisciplinary international expert consensus on perioperative airway management.Translational lung cancer research · 2025Review
- Anesthetic predictors for postoperative pneumonia in patients with non-small cell lung cancer.Journal of thoracic disease · 2024Article
- [Current approaches to anesthetic management in thoracic surgery-An evaluation from the German Thoracic Registry].Die Anaesthesiologie · 2022Article
- Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.Biochemical and biophysical research communications · 2021Article
- The Effects of Sevoflurane vs. Propofol for Inflammatory Responses in Patients Undergoing Lung Resection: A Meta-Analysis of Randomized Controlled Trials.Frontiers in surgery · 2021Article
- Laminin degradation by matrix metalloproteinase 9 promotes ketamine-induced neuronal apoptosis in the early developing rat retina.CNS neuroscience & therapeutics · 2020Article
- Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care.Perioperative medicine (London, England) · 2020Article
- The role of Journal of Anesthesia as a flagship anesthesia journal in Asia.Journal of anesthesia · 2018Article
- Anesthesia and fast-track in video-assisted thoracic surgery (VATS): from evidence to practice.Journal of thoracic disease · 2018Review
- Anesthesia and analgesia: how does the role of anesthetists changes in the ERAS program for VATS lobectomy.Journal of visualized surgery · 2018Article
- Effects of sevoflurane and propofol on the development of pneumonia after esophagectomy: a retrospective cohort study.BMC anesthesiology · 2017Article
- Comparing Postoperative Complications and Inflammatory Markers Using Total Intravenous Anesthesia Versus Volatile Gas Anesthesia for Pancreatic Cancer Surgery.Anesthesiology and pain medicine · 2017Article
- [Perioperative management of transthoracic oesophagectomies : Fundamentals of interdisciplinary care and new approaches to accelerated recovery after surgery].Der Anaesthesist · 2016Review
- The hypoxic pulmonary vasoconstriction: From physiology to clinical application in thoracic surgery.Saudi journal of anaesthesiaReview
- Inhalational versus intravenous anesthetics during one lung ventilation in elective thoracic surgeries: A narrative review.Saudi journal of anaesthesiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this meta-analysis is to compare the potential effects of inhalation anesthetics with total intravenous anesthetics on alveolar cytokine expression and lung-related clinical outcomes in patients undergoing one-lung ventilation (OLV) for thoracic surgery.
methodsWe retrieved the PubMed, EMBASE, and the Cochrane Library respectively to identify randomized controlled trials comparing different anesthetics (volatile anesthetics vs. intravenous anesthetics) on the pulmonary inflammatory response to OLV. The primary outcomes were the levels of alveolar concentrations of inflammatory cytokines.
resultsEight randomized controlled trials that included 365 patients were screened. Overall, there were significant differences in the concentration of alveolar inflammatory mediators between volatile group and intravenous group, in which volatile group had lower levels of TNF-α (SMD -1.51; 95 % CI -2.15 to -0.87; p < 0.001), IL-6 (SMD -0.70; 95 % CI -0.99 to -0.41; p < 0.001) and IL-8 (SMD -1.32; 95 % CI -2.20 to -0.45; p = 0.003). The overall number of pulmonary complications in the volatile group was smaller (RR 0.42; 95 % CI 0.23-0.77; p = 0.005) and patients in that group had significantly abridged hospitalization stay (WMD -3.59 days; 95 % CI -5.70 to -1.48 days; p = 0.001).
conclusionsInhalation anesthetics might be preferable in patients undergoing OLV for thoracic surgery and their protective effects might work via attenuating inflammatory responses.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.