Evidence map›Paper›PMID 25716357›Full record

SynthesisNeurology2015

Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis.

Yue Leng, Francesco P Cappuccio, Nick W J Wainwright, Paul G Surtees, Robert Luben, Carol Brayne, Kay-Tee Khaw

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 13 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 13 syntheses or guidelines pooled it, 241 citations in OpenAlex.

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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yue LengFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK. yl411@medschl.cam.ac.uk.
Francesco P CappuccioFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
Nick W J WainwrightFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
Paul G SurteesFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
Robert LubenFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
Carol BrayneFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
Kay-Tee KhawFrom the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
University of Warwick · GB

Funding

Cancer Research UK C864/A14136Cancer Research UK SP2024/0204Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G9502233
6 · The paper itself

Abstract

objectiveTo study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis.

methodsThe prospective study included 9,692 stroke-free participants aged 42-81 years from the European Prospective Investigation into Cancer-Norfolk cohort. Participants reported sleep duration in 1998-2000 and 2002-2004, and all stroke cases were recorded until March 31, 2009. For the meta-analysis, we searched Ovid Medline, EMBASE, and the Cochrane Library for prospective studies published until May 2014, and pooled effect estimates using a weighted random-effect model.

resultsAfter 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep was significantly associated with an increased risk of stroke (hazard ratio [HR] = 1.46 [95% confidence interval (CI) 1.08, 1.98]) after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep was smaller (and not statistically significant) (HR = 1.18 [95% CI 0.91, 1.53]). There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep. These were compatible with the pooled HRs from an updated meta-analysis, which were 1.15 (1.07, 1.24) and 1.45 (1.30, 1.62) for short and long sleep duration, respectively.

conclusionsThis prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population.

Indexed as

SleepAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsSleep DeprivationStrokeTime Factors

Identifiers

PMID25716357
PMCPMC4371404
OpenAlexW2135549297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.