ArticlePsychopharmacology2015
Altered spontaneous brain activity in heavy smokers revealed by regional homogeneity.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.Addiction biology · 2025Pooled it
- The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- The resting-state brain activity signatures for addictive disorders.Med (New York, N.Y.) · 2024Pooled it
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.BMC psychiatry · 2025Article
- Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males.Frontiers in psychiatry · 2025Article
- Increased spontaneous activity of the superior frontal gyrus with reduced functional connectivity to visual attention areas and cerebellum in male smokers.Frontiers in human neuroscience · 2023Article
- Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder.Journal of behavioral addictions · 2022Review
- Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers.Frontiers in psychiatry · 2022Article
- Sex-Dependent Alterations of Regional Homogeneity in Cigarette Smokers.Frontiers in psychiatry · 2022Article
- Explore the effects of overweight and smoking on spontaneous brain activity: Independent and reverse.Frontiers in neuroscience · 2022Article
- Association between functional brain alterations and neuropsychological scales in male chronic smokers using resting-state fMRI.Psychopharmacology · 2021Article
- Cerebellar Gray Matter Reductions Associate With Decreased Functional Connectivity in Nicotine-Dependent Individuals.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- [Research on the rest functional magnetic resonance imaging before and after smoking cessation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study.Scientific reports · 2017Article
- Combining Multiple Resting-State fMRI Features during Classification: Optimized Frameworks and Their Application to Nicotine Addiction.Frontiers in human neuroscience · 2017Article
- Hyper-resting brain entropy within chronic smokers and its moderation by Sex.Scientific reports · 2016Article
- Functional Connectivity Abnormalities of Brain Regions with Structural Deficits in Young Adult Male Smokers.Frontiers in human neuroscience · 2016Article
- Resting-state functional connectivity and nicotine addiction: prospects for biomarker development.Annals of the New York Academy of Sciences · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleTask-state and resting-state functional magnetic resonance imaging (fMRI) studies have revealed different brain responses in chronic cigarette smokers compared with healthy controls. However, little is known about the differences between chronic cigarette smokers and healthy subjects regarding the local synchronization of spontaneous brain activity in the resting state.
objectivesIn this study, we used regional homogeneity (ReHo) analysis based on resting-state fMRI to investigate intrinsic brain activity in heavy smokers.
methodsThirty-one heavy smokers and 33 healthy non-smokers were included in this study. ReHo was used to measure spontaneous brain activity, and whole-brain voxel-wise comparisons of ReHo were performed to detect brain regions with altered spontaneous brain activity between groups.
resultsCompared with non-smokers, heavy smokers showed decreased ReHo primarily in brain regions associated with the default-mode, frontoparietal attention, and inhibitory control networks; heavy smokers showed increased ReHo predominately in regions related to motor planning.
conclusionsOur results suggest that heavy smokers may have altered spontaneous brain activity in some brain regions that are associated with higher cognitive networks. Moreover, our study improves the understanding of the effects of chronic cigarette smoking on spontaneous brain activity and the pathophysiological mechanisms of nicotine dependence.
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