ReviewBiomechanics and modeling in mechanobiology2015
Mechanics of the brain: perspectives, challenges, and opportunities.
Review in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
117 citing papers in PubMed, 366 citations in OpenAlex.
- Dynamic image-informed selection of biomechanical tumor growth models.Biomechanics and modeling in mechanobiology · 2026Article
- GLP-1 and the brain's powerhouse: a new perspective on the role of mitochondria in neuroprotection.Metabolic brain disease · 2026Review
- A novel spatiotemporal decomposition and identification of sparse equations for human brain deformation.Scientific reports · 2026Article
- Multiscale measurement of brain tissue and cell biomechanics using a mouse model.Biophysics reports · 2025Article
- Gelatin Methacrylate Macroporous Cell Scaffold Fabrication via One-Pot Aqueous Two-Phase Separation.Journal of biomedical materials research. Part B, Applied biomaterials · 2025Article
- A Comprehensive Analysis of Inconsistencies in the Brain's Conventional Ex Vivo Mechanical Experiments.Annals of biomedical engineering · 2025Review
- Evaluating the Performance and Repeatability of Poroelastic and Poroviscoelastic Models in Intrinsic MR Elastography.NMR in biomedicine · 2025Article
- Exploring hyperelastic material model discovery for human brain cortex: Multivariate analysis vs. artificial neural network approaches.Journal of the mechanical behavior of biomedical materials · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization.Materials today. Bio · 2025Article
- Full-field, frequency-domain comparison of simulated and measured human brain deformation.Biomechanics and modeling in mechanobiology · 2025Article
- Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling.Journal of the Royal Society, Interface · 2025Review
- CSF production rate, resistance to reabsorption, and intracranial pressure: a systematic review and meta-analysis.Brain communications · 2025Review
- A universal material model subroutine for soft matter systems.Engineering with computers · 2025Article
- Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters!Interface focus · 2024Article
- Cyclic muscle contractions reinforce the actomyosin motors and mediate the full elongation ofeLife · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- A Systems Approach to Biomechanics, Mechanobiology, and Biotransport.Journal of biomechanical engineering · 2024Article
- Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke.PNAS nexus · 2024Article
- Unlocking stroke prediction: Harnessing projection-based statistical feature extraction with ML algorithms.Heliyon · 2024Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
Abstract
The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function. This opinion piece synthesizes expertise in applied mathematics, solid and fluid mechanics, biomechanics, experimentation, material sciences, neuropathology, and neurosurgery to address today's open questions at the forefront of neuromechanics. We critically review the current literature and discuss challenges related to neurodevelopment, cerebral edema, lissencephaly, polymicrogyria, hydrocephaly, craniectomy, spinal cord injury, tumor growth, traumatic brain injury, and shaken baby syndrome. The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information from the molecular via the cellular and tissue all the way to the organ level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.