ReviewAlcohol (Fayetteville, N.Y.)2015
Ethanol and corticotropin releasing factor receptor modulation of central amygdala neurocircuitry: An update and future directions.
Review in Alcohol (Fayetteville, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry.Frontiers in molecular neuroscience · 2022Review
- Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala.Neuropharmacology · 2020Article
- Optogenetic investigation of neural mechanisms for alcohol-use disorder.Alcohol (Fayetteville, N.Y.) · 2019Review
- Acute alcohol administration dampens central extended amygdala reactivity.Scientific reports · 2018Article
- CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety.Alcohol (Fayetteville, N.Y.) · 2018Review
- Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of ClNeuroscience letters · 2018Article
- Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior.Psychopharmacology · 2018Article
- The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective.Neuropharmacology · 2017Review
- From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety.Brain structure & function · 2017Article
- A Functional Switch in Tonic GABA Currents Alters the Output of Central Amygdala Corticotropin Releasing Factor Receptor-1 Neurons Following Chronic Ethanol Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.Nature reviews. Neuroscience · 2016Review
- Persistent adaptation by chronic alcohol is facilitated by neuroimmune activation linked to stress and CRF.Alcohol (Fayetteville, N.Y.) · 2016Review
- Ethanol produces corticotropin-releasing factor receptor-dependent enhancement of spontaneous glutamatergic transmission in the mouse central amygdala.Alcoholism, clinical and experimental research · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The central amygdala is a critical brain region for many aspects of alcohol dependence. Much of the work examining the mechanisms by which the central amygdala mediates the development of alcohol dependence has focused on the interaction of acute and chronic ethanol with central amygdala corticotropin releasing factor signaling. This work has led to a great deal of success in furthering the general understanding of central amygdala neurocircuitry and its role in alcohol dependence. Much of this work has primarily focused on the hypothesis that ethanol utilizes endogenous corticotropin releasing factor signaling to upregulate inhibitory GABAergic transmission in the central amygdala. Work that is more recent suggests that corticotropin releasing factor also plays an important role in mediating anxiety-like behaviors via the enhancement of central amygdala glutamatergic transmission, implying that ethanol/corticotropin releasing factor interactions may modulate excitatory neurotransmission in this brain region. In addition, a number of studies utilizing optogenetic strategies or transgenic mouse lines have begun to examine specific central amygdala neurocircuit dynamics and neuronal subpopulations to better understand overall central amygdala neurocircuitry and the role of neuronal subtypes in mediating anxiety-like behaviors. This review will provide a brief update on this literature and describe some potential future directions that may be important for the development of better treatments for alcohol addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.