SynthesisMedical science monitor : international medical journal of experimental and clinical research2015
Telomere reverse transcriptase (TERT) rs2735940 increases cancer risk.
Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Spotlight onGenes · 2023Article
- MassARRAY-based single nucleotide polymorphism analysis in breast cancer of north Indian population.BMC cancer · 2020Article
- Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel.British journal of cancer · 2018Article
- Telomere Length Assessment for Prediction of Organ Transplantation Outcome. Future or Failure: A Review of the Literature.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTelomerase reverse transcriptase (TERT) rs2735940 polymorphism was found to be associated with increased cancer risk. However, recent studies reported controversial results. The aim of our study was to detect its relationship with cancer risk. MATERIAL AND
methodsEMBASE and PubMed databases were searched for all publications until October 2014. ORs and 95% CIs were applied to investigate the association in the random-effects model.
resultsThirteen case-control studies with 19385 cases and 17558 controls were included in this study. We found a significant association between cancer risk and TERT rs2735940 polymorphism (OR=1.06, 95% CI 1.02-1.11, P=0.005). In the subgroup analysis by ethnicity, a marginal association was found in Caucasians (OR=1.05, 95% CI 1.00-1.10, P=0.05), but not in Asians (OR=1.01, 95% CI 0.82-1.24, P=0.93). In the subgroup analysis by cancer site, this polymorphism was significantly associated with lung cancer risk (OR=1.08, 95% CI 1.02-1.13, P=0.004).
conclusionsTERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.
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Registered trials
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