ArticleScientific reports2015
Precision assembly of complex cellular microenvironments using holographic optical tweezers.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Acoustic Tweezers-Assisted Biomaterial Molding in Petri Dishes (TAMP) for Engineering Glioma Tissues With Controlled Cellular and Extracellular Matrix Architectures.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A Single-Cell Bioprinting Method to Reconstruct Native Cellular Microenvironments with Subcellular Resolution.Research square · 2026Article
- Strategies to control cellular spatial organization in microphysiological systems.Microsystems & nanoengineering · 2026Review
- Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026Review
- Optical Micromanipulations Based on Model Predictive Control of Thermoviscous Flows.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Harnessing optical forces with advanced nanophotonic structures: principles and applications.Discover nano · 2025Review
- Mechanoactivation of Single Stem Cells in Microgels Using a 3D-Printed Stimulation Device.Small methods · 2024Article
- Optical tweezers in biomedical research - progress and techniques.Journal of medicine and life · 2024Review
- Advances in Nanoarchitectonics: A Review of "Static" and "Dynamic" Particle Assembly Methods.Materials (Basel, Switzerland) · 2024Review
- Advanced Mechanical Testing Technologies at the Cellular Level: The Mechanisms and Application in Tissue Engineering.Polymers · 2023Review
- Optically driven microtools with an antibody-immobilised surface for on-site cell assembly.IET nanobiotechnology · 2023Article
- Optical trapping with holographically structured light for single-cell studies.Biophysics reviews · 2023Review
- Middle-out methods for spatiotemporal tissue engineering of organoids.Nature reviews bioengineering · 2023Review
- Dynamic patterning of microparticles with acoustic impulse control.Scientific reports · 2022Article
- Article
- Synthetic developmental biology: Engineering approaches to guide multicellular organization.Stem cell reports · 2022Review
- Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects.Micromachines · 2021Review
- Surface acoustic wave (SAW) techniques in tissue engineering.Cell and tissue research · 2021Review
- Laser induced forward transfer isolating complex-shaped cell by beam shaping.Biomedical optics express · 2021Article
- A virtual reality interface for the immersive manipulation of live microscopic systems.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The accurate study of cellular microenvironments is limited by the lack of technologies that can manipulate cells in 3D at a sufficiently small length scale. The ability to build and manipulate multicellular microscopic structures will facilitate a more detailed understanding of cellular function in fields such as developmental and stem cell biology. We present a holographic optical tweezers based technology to accurately generate bespoke cellular micro-architectures. Using embryonic stem cells, 3D structures of varying geometries were created and stabilized using hydrogels and cell-cell adhesion methods. Control of chemical microenvironments was achieved by the temporal release of specific factors from polymer microparticles positioned within these constructs. Complex co-culture micro-environmental analogues were also generated to reproduce structures found within adult stem cell niches. The application of holographic optical tweezers-based micromanipulation will enable novel insights into biological microenvironments by allowing researchers to form complex architectures with sub-micron precision of cells, matrices and molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.