Evidence map›Paper›PMID 25715948›Full record

ArticleScientific reports2015

Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking.

Nazmiye B Yapici, Yue Bi, Pengfei Li, Xin Chen, Xin Yan, Srinivas Rao Mandalapu, Megan Faucett, Steffen Jockusch, Jingfang Ju, K Michael Gibson and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  8. Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells.Journal of controlled release : official journal of the Controlled Release Society · 2022
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  14. Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nazmiye B YapiciDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Yue BiSecond Hospital of HeBei Medical University, Shijiazhuang, China 050000.
Pengfei LiSecond Hospital of HeBei Medical University, Shijiazhuang, China 050000.
Xin ChenDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Xin YanDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Srinivas Rao MandalapuDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Megan FaucettDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Steffen JockuschDepartment of Chemistry, Columbia University, NY 10027.
Jingfang JuTranslational Research Laboratory, Stony Brook Medicine, Stony Brook, NY 11794.
K Michael GibsonExperimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane WA 99202.
William J PavanNational Human Genome Research Institute, NIH, Bethesda, Maryland 20892.
Lanrong BiDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.

Funding

THE USE OF THE MOUSE NPC MODEL TO CLONE THE HUMAN DISEASE GENEZIAHG000068 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PAVAN, WILLIAM J · 2009 to 2023
$6.0M
Enhancing the "Barcode" Readability of Color-Labeled Molecular Tags by Linker EngR15GM088795 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI BI, LANRONG · 2009 to 2009
$202k
NIGMS NIH HHS GM088795-01NIGMS NIH HHS R15 GM088795
6 · The paper itself

Abstract

We report the design, synthesis and application of several new fluorescent probes (LysoProbes I-VI) that facilitate lysosomal pH monitoring and characterization of lysosome-dependent apoptosis. LysoProbes are superior to commercially available lysosome markers since the fluorescent signals are both stable and highly selective, and they will aid in characterization of lysosome morphology and trafficking. We predict that labeling of cancer cells and solid tumor tissues with LysoProbes will provide an important new tool for monitoring the role of lysosome trafficking in cancer invasion and metastasis.

Indexed as

Fluorescent DyesHeLa CellsHumansHydrogen-Ion ConcentrationLactoseLysosomesSpectrometry, FluorescenceStaining and LabelingFluorescent DyesLactose

Identifiers

PMID25715948
PMCPMC4341211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.