Evidence map›Paper›PMID 25715878›Full record

ArticleActa orthopaedica2015

Increased risk of revision of cementless stemmed total hip arthroplasty with metal-on-metal bearings.

Claus Varnum, Alma B Pedersen, Keijo Mäkelä, Antti Eskelinen, Leif Ivar Havelin, Ove Furnes, Johan Kärrholm, Göran Garellick, Søren Overgaard

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Acta orthopaedica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04585022 (Whole Blood Metal Ion Concentrations in Metal-on-metal Total Hip Arthroplasty and Hip Resurfacing - A Randomized Controlled Trial With 5-years Follow up Including 75 Patients), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04585022 naterminatednot on this map

Whole Blood Metal Ion Concentrations in Metal-on-metal Total Hip Arthroplasty and Hip Resurfacing - A Randomized Controlled Trial With 5-years Follow up Including 75 Patients

TypeinterventionalSponsorHvidovre University HospitalRan2006 to 2017Enrolled75ConditionsOsteoarthritis, HipArmsMagnum, Zimmer Biomet, Warsaw, IN, Recap, Zimmer Biomet, Warsaw, IN
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  8. Long-term results of the MJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2018
    Article
  9. Article
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  11. Development of a pilot cartilage surgery register.BMC musculoskeletal disorders · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Claus VarnumDepartment of Orthopaedic Surgery, Section for Hip and Knee Replacement , Vejle Hospital , Vejle.
Alma B Pedersen
Keijo Mäkelä
Antti Eskelinen
Leif Ivar Havelin
Ove Furnes
Johan Kärrholm
Göran Garellick
Søren Overgaard
The Swedish Hip Arthroplasty Register · SEAarhus University Hospital · DKCoxa Hospital · FIHaukeland University Hospital · NOOdense University Hospital · DKTurku University Hospital · FIUniversity of Bergen · NOUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeData from the national joint registries in Australia and England and Wales have revealed inferior medium-term survivorship for metal-on-metal (MoM) total hip arthroplasty (THA) than for metal-on-polyethylene (MoP) THA. Based on data from the Nordic Arthroplasty Register Association (NARA), we compared the revision risk of cementless stemmed THA with MoM and MoP bearings and we also compared MoM THA to each other. PATIENTS AND

methodsWe identified 32,678 patients who were operated from 2002 through 2010 with cementless stemmed THA with either MoM bearings (11,567 patients, 35%) or MoP bearings (21,111 patients, 65%). The patients were followed until revision, death, emigration, or the end of the study period (December 31, 2011), and median follow-up was 3.6 (interquartile range (IQR): 2.4-4.8) years for MoM bearings and 3.4 (IQR: 2.0-5.8) years for MoP bearings. Multivariable regression in the presence of competing risk of death was used to assess the relative risk (RR) of revision for any reason (with 95% confidence interval (CI)).

resultsThe cumulative incidence of revision at 8 years of follow-up was 7.0% (CI: 6.0-8.1) for MoM bearings and 5.1% (CI: 4.7-5.6) for MoP bearings. At 6 years of follow-up, the RR of revision for any reason was 1.5 (CI: 1.3-1.7) for MoM bearings compared to MoP bearings. The RR of revision for any reason was higher for the ASR (adjusted RR = 6.4, CI: 5.0-8.1), the Conserve Plus (adjusted RR = 1.7, CI: 1.1-2.5) and "other" acetabular components (adjusted RR = 2.4, CI: 1.5-3.9) than for MoP THA at 6 years of follow-up.

interpretationAt medium-term follow-up, the survivorship for cementless stemmed MoM THA was inferior to that for MoP THA, and metal-related problems may cause higher revision rates for MoM bearings with longer follow-up.

Indexed as

Hip ProsthesisMetalsAdultAgedAged, 80 and overArthroplasty, Replacement, HipFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisPolyethyleneProsthesis FailureMetalsPolyethylene

Identifiers

PMID25715878
PMCPMC4513606
OpenAlexW2060681277

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.