ArticleThe journal of physiological sciences : JPS2015
Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum.
Article in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data.International journal of molecular sciences · 2025Review
- Neurosteroids: a lifelong impact on brain health.Frontiers in behavioral neuroscience · 2025Review
- Brain-derived estrogen and neural function.Neuroscience and biobehavioral reviews · 2022Review
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats.Translational stroke research · 2019Article
- Transcriptome-wide piRNA profiling in human brains for aging genetic factors.Jacobs journal of genetics · 2019Article
- Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration: therapeutic potential?Journal of neuroinflammation · 2018Review
- Androgen Regulation of the Mesocorticolimbic System and Executive Function.Frontiers in endocrinology · 2018Review
- HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Tyramide Signal Amplification Permits Immunohistochemical Analyses of Androgen Receptors in the Rat Prefrontal Cortex.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Sex and the development of Alzheimer's disease.Journal of neuroscience research · 2017Review
- Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases.Frontiers in aging neuroscience · 2017Review
- Article
- Prostate Cancer: Is It a Battle Lost to Age?Geriatrics (Basel, Switzerland) · 2016Review
- The suprachiasmatic nucleus: age-related decline in biological rhythms.The journal of physiological sciences : JPS · 2016Review
- Puerperal and parental experiences alter rat preferences for pup odors via changes in the oxytocin system.The Journal of reproduction and development · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated age-induced changes in mRNA expression profiles of sex-steroidogenic enzymes and sex-steroid receptors in 3-, 12-, and 24-month-old male rat brain subregions [cerebral cortex (CC), hypothalamus (Hy) and cerebellum (CL)]. In many cases, the expression levels of mRNA decreased with age for androgen synthesis enzyme systems, including Cyp17a1, Hsd17b and Srd5a in the CC and CL, but not in the Hy. Estradiol synthase Cyp19a1 did not show age-induced decline in the Hy, and nearly no expression of Cyp19a1 was observed in the CC and CL over 3-24 m. Androgen receptor Ar increased in the Hy but decreased in the CC with age. Estrogen receptor Esr1 increased in the CC and Hy, and did not change in the CL with age. Esr2 did not change in the CC and Hy, but decreased in the CL with age. As a comparison, age-induced changes of brain-derived neurotrophic factor mRNA were also investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.