Evidence map›Paper›PMID 25715741›Full record

ReviewCellular and molecular life sciences : CMLS2015

Mononuclear phagocyte-mediated antifungal immunity: the role of chemotactic receptors and ligands.

Muthulekha Swamydas, Timothy J Break, Michail S Lionakis

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Hyphae ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
  5. Genetic susceptibility to fungal infection in children.Current opinion in pediatrics · 2020
    Review
  6. Article
  7. Article
  8. Review
  9. Innate Immunity to Mucosal Candida Infections.Journal of fungi (Basel, Switzerland) · 2017
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muthulekha SwamydasFungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Building 10, Room 11C102, Bethesda, MD, 20892, USA.
Timothy J Break
Michail S Lionakis

Funding

Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9M
Intramural NIH HHS ZIA AI001175
6 · The paper itself

Abstract

Over the past two decades, fungal infections have emerged as significant causes of morbidity and mortality in patients with hematological malignancies, hematopoietic stem cell or solid organ transplantation and acquired immunodeficiency syndrome. Besides neutrophils and CD4(+) T lymphocytes, which have long been known to play an indispensable role in promoting protective antifungal immunity, mononuclear phagocytes are now being increasingly recognized as critical mediators of host defense against fungi. Thus, a recent surge of research studies has focused on understanding the mechanisms by which resident and recruited monocytes, macrophages and dendritic cells accumulate and become activated at the sites of fungal infection. Herein, we critically review how a variety of G-protein coupled chemoattractant receptors and their ligands mediate mononuclear phagocyte recruitment and effector function during infection by the most common human fungal pathogens.

Indexed as

AspergillosisCandidiasisCD4-Positive T-LymphocytesChemotactic FactorsCryptococcosisDendritic CellsHumansImmunity, InnateMacrophagesMonocytesMononuclear Phagocyte SystemMycosesNeutrophilsReceptors, G-Protein-CoupledChemotactic FactorsReceptors, G-Protein-Coupled

Identifiers

PMID25715741
PMCPMC4430359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.