Evidence map›Paper›PMID 25715644›Full record

ReviewClinical microbiology reviews2015

Human infections with Sarcocystis species.

Ronald Fayer, Douglas H Esposito, Jitender P Dubey

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Molecular and Microscopic Identification ofAnimals : an open access journal from MDPI · 2026
    Article
  5. Epidemiology and First Molecular Characterization ofAnimals : an open access journal from MDPI · 2026
    Article
  6. First Identification of Pathogenic and Zoonotic-RelevantAnimals : an open access journal from MDPI · 2026
    Article
  7. Molecular Evidence of the Role of the Red Fox (Animals : an open access journal from MDPI · 2026
    Article
  8. Review
  9. High frequency of DNA detection ofFood and waterborne parasitology · 2025
    Article
  10. Article
  11. Detection ofInternational journal for parasitology. Parasites and wildlife · 2025
    Article
  12. Article
  13. The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  14. Detection ofFood and waterborne parasitology · 2025
    Article
  15. European Pine Marten (Veterinary sciences · 2025
    Article
  16. Prevalence and molecular analysis ofVeterinary and animal science · 2025
    Article
  17. Article
  18. Article
  19. The impact ofFrontiers in veterinary science · 2025
    Article
  20. Detection ofFrontiers in veterinary science · 2025
    Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ronald FayerU.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA ronald.fayer@ars.usda.gov.
Douglas H EspositoDivision of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jitender P DubeyU.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA.
Agricultural Research Service · USNational Center for Emerging and Zoonotic Infectious Diseases · USUnited States Department of Agriculture · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent outbreaks of muscular sarcocystosis among tourists visiting islands in Malaysia have focused international attention on sarcocystosis, a disease once considered rare in humans. Sarcocystis species require two hosts, definitive and intermediate, to complete their life cycle. Humans can serve as definitive hosts, with intestinal sarcocystosis for two species acquired from eating undercooked meat: Sarcocystis hominis, from beef, and Sarcocystis suihominis, from pork. Symptoms such as nausea, stomachache, and diarrhea vary widely depending on the number of cysts ingested but appear more severe with pork than with beef. Humans serve as intermediate hosts for Sarcocystis nesbitti, a species with a reptilian definitive host, and possibly other unidentified species, acquired by ingesting sporocysts from feces-contaminated food or water and the environment; infections have an early phase of development in vascular endothelium, with illness that is difficult to diagnose; clinical signs include fever, headache, and myalgia. Subsequent development of intramuscular cysts is characterized by myositis. Presumptive diagnosis based on travel history to tropical regions, elevated serum enzyme levels, and eosinophilia is confirmed by finding sarcocysts in muscle biopsy specimens. There is no vaccine or confirmed effective antiparasitic drug for muscular sarcocystosis, but anti-inflammatory drugs may reduce symptoms. Prevention strategies are also discussed.

Indexed as

SarcocystosisAnimalsEnzymesHumansIntestinesLife Cycle StagesMeatMusclesSarcocystisTravelEnzymes

Identifiers

PMID25715644
PMCPMC4402950
OpenAlexW2132132889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.