ArticleChemical senses2015
Postoral glucose sensing, not caloric content, determines sugar reward in C57BL/6J mice.
Article in Chemical senses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Preference and behavioral responses to synbiotic supplementation via drinking water in laying hens under social stress.Poultry science · 2026Article
- Transcutaneous Vagus Nerve Stimulation Effects on Flavor-Evoked Electroencephalogram and Eye-Blink Rate.Brain and behavior · 2025Article
- Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences.Physiology & behavior · 2024Article
- Gut-brain circuits for fat preference.Nature · 2022Article
- The neural basis of sugar preference.Nature reviews. Neuroscience · 2022Review
- Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits.Nature metabolism · 2022Article
- Internal senses of the vagus nerve.Neuron · 2022Review
- What Does the Taste System Tell Us About the Nutritional Composition and Toxicity of Foods?Handbook of experimental pharmacology · 2022Article
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Sucralose and Cardiometabolic Health: Current Understanding from Receptors to Clinical Investigations.Advances in nutrition (Bethesda, Md.) · 2021Review
- The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders.Molecular metabolism · 2021Review
- Chronic stress accelerates the process of gastric precancerous lesions in rats.Journal of Cancer · 2021Article
- Extended access self-administration of methamphetamine is associated with age- and sex-dependent differences in drug taking behavior and recognition memory in rats.Behavioural brain research · 2020Article
- Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity.Neuron · 2020Article
- The gut-brain axis mediates sugar preference.Nature · 2020Article
- From appetite setpoint to appetition: 50years of ingestive behavior research.Physiology & behavior · 2018Review
- SGLT6 - A pharmacological target for the treatment of obesity?Adipocyte · 2018Article
- Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward.Current biology : CB · 2017Article
- Carbohydrate craving: not everything is sweet.Current opinion in clinical nutrition and metabolic care · 2017Review
- Flavor preferences conditioned by nutritive and non-nutritive sweeteners in mice.Physiology & behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies suggest that because of their energy value, sugars are more rewarding than non-caloric sweeteners. However, intragastric infusion data indicate that sugars differ in their postoral appetite-stimulating effects. We therefore compared the preference for isocaloric 8% sucrose, glucose, and fructose solutions with that of a non-caloric sweetener solution (0.8% sucralose) in C57BL/6J mice. Brief 2-bottle tests indicated that sucralose was isopreferred to sucrose but more preferred than glucose or fructose. Yet, in long-term tests, the mice preferred sucrose and glucose, but not fructose to sucralose. Additional experiments were conducted with a non-caloric 0.1% sucralose + 0.1% saccharin mixture (S + S), which does not have the postoral inhibitory effects of 0.8% sucralose. The S + S was preferred to fructose in brief and long-term choice tests. S + S was also preferred to glucose and sucrose in brief tests, but the sugars were preferred in long-term tests. In progressive ratio tests, non-deprived and food-deprived mice licked more for glucose but not fructose than for S + S. These findings demonstrate that the nutrient-specific postoral actions, not calories per se, determine the avidity for sugar versus non-caloric sweeteners. Furthermore, sweet taste intensity and potential postoral inhibitory actions must be considered in comparing non-caloric and caloric sweeteners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.