Evidence map›Paper›PMID 25715105›Full record

ArticleAIDS (London, England)2015

High HIV burden among people who inject drugs in 15 Indian cities.

Gregory M Lucas, Sunil S Solomon, Aylur K Srikrishnan, Alok Agrawal, Syed Iqbal, Oliver Laeyendecker, Allison M McFall, Muniratnam S Kumar, Elizabeth L Ogburn, David D Celentano and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in AIDS (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01686750 (A Cluster Randomized Trial of Integrated Care Centers to Improve Access to HIV Prevention, Testing, and Treatment Services Among High-Risk Vulnerable Populations in India), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01686750 nacompletednot on this map

A Cluster Randomized Trial of Integrated Care Centers to Improve Access to HIV Prevention, Testing, and Treatment Services Among High-Risk Vulnerable Populations in India

TypeinterventionalSponsorJohns Hopkins UniversityRan2012 to 2017Enrolled21,726ConditionsHIV InfectionArmsIntegrated care centers
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  9. HIV care continuum among men who have sex with men and persons who inject drugs in India: barriers to successful engagement.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Gregory M LucasaJohns Hopkins University School of Medicine, Department of Medicine, Baltimore, Maryland, USA bY.R. Gaitonde Centre for AIDS Research and Education, Chennai, Tamil Nadu cAll India Institute of Medical Sciences, Department of Psychiatry, New Delhi, India dLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health eJohns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Sunil S Solomon
Aylur K Srikrishnan
Alok Agrawal
Syed Iqbal
Oliver Laeyendecker
Allison M McFall
Muniratnam S Kumar
Elizabeth L Ogburn
David D Celentano
Suniti Solomon
Shruti H Mehta
YR Gaitonde Centre for AIDS Research and Education · INJohns Hopkins University · USAll India Institute of Medical Sciences · INJohns Hopkins Medicine · USNational Institute of Allergy and Infectious Diseases · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Bryan Lau · 2012 to 2026
$67.0M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Integrated Care Clinics for IDUs in India: a cluster randomized trialR01DA032059 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M, MEHTA, SHRUTI H · 2011 to 2015
$6.3M
Preventing HIV Infection Among MSM in Southern IndiaR01MH089266 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CELENTANO, DAVID D. · 2010 to 2015
$2.9M
Treatment outcomes and comorbidity in HIV-infected IDUK24DA035684 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2014 to 2024
$1.5M
Intramural NIH HHSNIAID NIH HHS P30 AI094189NIDA NIH HHS K24 DA035684NIDA NIH HHS R01 DA032059NIMH NIH HHS R01 MH089266NIMH NIH HHS R01 MH 89266
6 · The paper itself

Abstract

backgroundInjecting drug use has historically been the principal driver of the HIV epidemic in the northeast states of India. However, recent data indicate growing numbers of people who inject drugs (PWIDs) in north and central Indian cities.

methodsWe conducted face-to-face surveys among PWIDs in seven northeast and eight north/central Indian cities using respondent-driven sampling. We used a rapid HIV-testing protocol to identify seropositive individuals and multiassay algorithm to identify those with recent infection. We used multilevel regression models that incorporated sampling weights and had random intercepts for site to assess risk factors for prevalent and incident (recent) HIV infection.

resultsWe surveyed 14 481 PWIDs from 15 Indian cities between January and December 2013. Participants reported high rates of needle/syringe sharing. The median (site range) estimated HIV prevalence and incidence were 18.1% (5.9, 44.9) and 2.9 per 100 person-years (0, 12.4), respectively. HIV prevalence was higher in northeast sites, whereas HIV incidence was higher in north/central sites. The odds of prevalent HIV were over three-fold higher in women than in men. Other factors associated with HIV prevalence or incidence included duration since first injection, injection of pharmaceutical drugs, and needle/syringe sharing.

conclusionsThe burden of HIV infection is high among PWIDs in India, and may be increasing in cities where injecting drug use is emerging. Women who inject drugs were at substantially higher risk for HIV than men - a situation that may be mediated by dual injection-related and sexual risks.

Indexed as

AdultCitiesCross-Sectional StudiesFemaleHIV InfectionsHumansIncidenceIndiaInterviews as TopicMalePrevalenceRisk AssessmentSex FactorsSubstance Abuse, Intravenous

Identifiers

PMID25715105
PMCPMC4346289
OpenAlexW2024540384

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.