ArticleeLife2015
The genetic architecture of gene expression levels in wild baboons.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 116 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Admixture influences the genetic architecture of DNA methylation in a wild primate hybrid zone.Genome biology · 2026Article
- Widespread sex-biased gene expression reflects female-biased longevity in a species with environmental sex determination.bioRxiv : the preprint server for biology · 2025Article
- Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque.Molecular ecology · 2025Article
- Genome-wide allele-specific expression in multi-tissue samples from healthy male baboons reveals the transcriptional complexity of mammals.Cell genomics · 2025Article
- Diet composition impacts eQTL discovery across multiple tissues in baboons.Cell genomics · 2024Article
- DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA methylation signatures of early life adversity are exposure-dependent in wild baboons.bioRxiv : the preprint server for biology · 2023Article
- Current advances in primate genomics: novel approaches for understanding evolution and disease.Nature reviews. Genetics · 2023Review
- The evolution of the human DNA replication timing program.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression.Molecular biology and evolution · 2022Article
- Selection against admixture and gene regulatory divergence in a long-term primate field study.Science (New York, N.Y.) · 2022Article
- Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- System drift and speciation.Evolution; international journal of organic evolution · 2022Article
- Estimating and accounting for unobserved covariates in high-dimensional correlated data.Journal of the American Statistical Association · 2022Article
- Transcriptome-wide association studies: a view from Mendelian randomization.Quantitative biology (Beijing, China) · 2021Article
- Efficient and effective control of confounding in eQTL mapping studies through joint differential expression and Mendelian randomization analyses.Bioinformatics (Oxford, England) · 2021Article
- Article
- Where Are the Disease-Associated eQTLs?Trends in genetics : TIG · 2021Review
- Statistical methods for mediation analysis in the era of high-throughput genomics: Current successes and future challenges.Computational and structural biotechnology journal · 2021Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Primate evolution has been argued to result, in part, from changes in how genes are regulated. However, we still know little about gene regulation in natural primate populations. We conducted an RNA sequencing (RNA-seq)-based study of baboons from an intensively studied wild population. We performed complementary expression quantitative trait locus (eQTL) mapping and allele-specific expression analyses, discovering substantial evidence for, and surprising power to detect, genetic effects on gene expression levels in the baboons. eQTL were most likely to be identified for lineage-specific, rapidly evolving genes; interestingly, genes with eQTL significantly overlapped between baboons and a comparable human eQTL data set. Our results suggest that genes vary in their tolerance of genetic perturbation, and that this property may be conserved across species. Further, they establish the feasibility of eQTL mapping using RNA-seq data alone, and represent an important step towards understanding the genetic architecture of gene expression in primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.