ArticleNuclear medicine communications2015
Glucose-corrected standardized uptake value in the differentiation of high-grade glioma versus post-treatment changes.
Article in Nuclear medicine communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Effects of blood glucose level on 18F-FDG uptake for PET/CT in normal organs: A systematic review.PloS one · 2018Pooled it
- An Evaluation Study of PET Image Quality Factors in Brain Tumor Diagnosis.Tomography (Ann Arbor, Mich.) · 2026Article
- The efficacy of short acquisition time usingEJNMMI research · 2024Article
- Combined amino acid PET-MRI for identifying recurrence in post-treatment gliomas: together we grow.European journal of hybrid imaging · 2021Article
- Quantitative FDG PET Assessment for Oncology Therapy.Cancers · 2021Review
- Multiparametric Evaluation in Differentiating Glioma Recurrence from Treatment-Induced Necrosis Using SimultaneousAJNR. American journal of neuroradiology · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundStandardized uptake values (SUVs) of fluorine-18 fluorodeoxyglucose PET ((18)F-FDG PET) are used widely to differentiate residual or recurrent high-grade gliomas from post-treatment changes in patients with brain tumors. The aim of this study is to assess the accuracy of SUV corrected by blood glucose level (SUV(gluc)) compared with various quantitative methods in this role. MATERIALS AND
methodsIn 55 patients with dynamic F-FDG PET scans, there were 97 glioma lesions: glioblastoma (n=60), grade III gliomas (n=22), grade III or IV gliomas (n=6), grade I/II (n=7), and prebiopsy lesions (n=2). The final actual diagnosis was made on the basis of pathology (n=33) and clinical outcome (n=64). Dynamic F-FDG PET scans were processed to generate parametric images of SUV(gluc), SUV(max), and glucose metabolic rate (GMR). Lesion to cerebellum ratios (SUV(Rc)) and contralateral white matter ratios (SUV(Rw)) were also measured. The SUV(gluc) was calculated as SUV(max)×blood glucose level/100.
resultsUsing the thresholds of SUV(max)>4.6, SUV(Rc)>0.9, SUV(Rw)>1.8, SUV(gluc)>4.3, and GMR>12.2 μmol/min/100 g to represent positivity for viable tumors, the accuracies were the same for the SUV(gluc) and SUV(Rw) (80%) and were higher than the conventional SUV(max) (72%). The area under the receiver operating characteristic curve for the SUV(gluc) (0.8933) was better than that for the SUV(max) (0.8266) (P<0.01) and was similar to those of the GMR (0.8622), SUV(Rc) (0.8606), and SUV(Rw) (0.8981).
conclusionThese results suggest that SUV(gluc) may aid in the differentiation of residual or recurrent high-grade tumor from post-treatment changes in patients with abnormal blood glucose levels. The simplicity of the SUV(gluc) avoids the complexity of kinetic analysis or the requirement of a reference tissue.
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