ReviewCurrent opinion in gastroenterology2015
Noninvasive assessment of liver function.
Review in Current opinion in gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03294850 (Evaluation of Biomarkers to Quantify Liver Pathology in Patients With Presumed Non-Alcoholic Steatohepatitis at Baseline and Following Bariatric Surgery), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Biomarkers to Quantify Liver Pathology in Patients With Presumed Non-Alcoholic Steatohepatitis at Baseline and Following Bariatric Surgery (BARI)
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.The American journal of gastroenterology · 2017Guideline
- Assessment of Haemodynamic Response to Nonselective Beta-Blockers in Portal Hypertension by Phase-Contrast Magnetic Resonance Angiography.BioMed research international · 2017Trial
- Evidence Supporting Utility of the Oral Cholate Challenge Test of Liver Function and Physiology to Aid Clinical Management: A Review of Analytical and Clinical Validation Studies.Gastro hep advances · 2026Review
- Oral curative therapeutic study of N-nitrosodiethylamine-induced mouse liver damage of chitosan-coated ursolic acid niosomes.Scientific reports · 2025Article
- Alterations in Liver Perfusion in Adults With Fontan Circulation as Assessed by Dual Cholate Clearance.Journal of the American Heart Association · 2025Observational
- Cholate Shunt, Oral Cholate Challenge and Endoscopic Lesions of Portal Hypertension: The SHUNT-V Study.Alimentary pharmacology & therapeutics · 2025Article
- Liver function and portal-systemic shunting quantified by the oral cholate challenge test and risk for large oesophageal varices.Alimentary pharmacology & therapeutics · 2024Article
- Advances in noninvasive measurement of liver function and physiology: The HepQuant DuO test.Basic & clinical pharmacology & toxicology · 2024Article
- Cost-effectiveness of an oral cholate challenge test for the management of patients at risk for large esophageal varices.PloS one · 2024Article
- The Oral Cholate Challenge Test Quantifies Risk for Liver-Related Clinical Outcomes in Primary Sclerosing Cholangitis.Gastro hep advances · 2024Article
- Effect of Hepatic Pathology on Liver Regeneration: The Main Metabolic Mechanisms Causing Impaired Hepatic Regeneration.International journal of molecular sciences · 2023Review
- Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver.Journal of medical biochemistry · 2023Article
- Noninvasive imaging of hepatic dysfunction: A state-of-the-art review.World journal of gastroenterology · 2022Review
- HepQuant SHUNT Detects Portal Hypertension in Early Stages of Clinically Compensated Chronic Liver Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Bibliometric-analysis visualization and review of non-invasive methods for monitoring and managing the portal hypertension.Frontiers in medicine · 2022Review
- Outcomes and potential surrogate markers for future clinical trials of non-alcoholic steatohepatitis cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2021Review
- Measurement and clinical usefulness of bilirubin in liver disease.Advances in laboratory medicine · 2021Review
- Limitations of non-invasive tests for assessment of liver fibrosis.JHEP reports : innovation in hepatology · 2020Review
- Road to identifying endpoint biomarkers in the treatment of nonalcoholic steatohepatitis: are we there yet?Hepatobiliary surgery and nutrition · 2020Article
- Assessing hepatic impairment in Fontan-associated liver disease using the HepQuant SHUNT test.Congenital heart disease · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purpose of reviewIt is our opinion that there is an unmet need in hepatology for a minimally or noninvasive test of liver function and physiology. Quantitative liver function tests define the severity and prognosis of liver disease by measuring the clearance of substrates whose uptake or metabolism is dependent upon liver perfusion or hepatocyte function. Substrates with high-affinity hepatic transporters exhibit high 'first-pass' hepatic extraction and their clearance measures hepatic perfusion. In contrast, substrates metabolized by the liver have low first-pass extraction and their clearance measures specific drug metabolizing pathways. RECENT
findingsWe highlight one quantitative liver function test, the dual cholate test, and introduce the concept of a disease severity index linked to clinical outcome that quantifies the simultaneous processes of hepatocyte uptake, clearance from the systemic circulation, clearance from the portal circulation, and portal-systemic shunting. SUMMARY: It is our opinion that dual cholate is a relevant test for defining disease severity, monitoring the natural course of disease progression, and quantifying the response to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.