ArticleAmerican journal of physiology. Endocrinology and metabolism2015
Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids.
Article in American journal of physiology. Endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Insulin signaling in PCOS/PMOS: molecular insights and clinical implications.Frontiers in endocrinology · 2026Review
- Metabolic Implications of PCOS.Current pediatrics reports · 2025Article
- Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity.Obesity (Silver Spring, Md.) · 2022Article
- Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity.Pediatric diabetes · 2021Article
- Accelerated subcutaneous abdominal stem cell adipogenesis predicts insulin sensitivity in normal-weight women with polycystic ovary syndrome.Fertility and sterility · 2021Article
- The Effect of RBP4 on microRNA Expression Profiles in Porcine Granulosa Cells.Animals : an open access journal from MDPI · 2021Article
- Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers.International journal of molecular sciences · 2021Review
- Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2021Article
- Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity.Metabolism open · 2021Article
- Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome.Trends in cardiovascular medicine · 2020Article
- Developmental programming of insulin resistance: are androgens the culprits?The Journal of endocrinology · 2020Review
- Metabolomics in Central Sensitivity Syndromes.Metabolites · 2020Review
- Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women.Mediators of inflammation · 2020Article
- Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS.BioMed research international · 2020Article
- Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).Clinical endocrinology · 2019Article
- Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.Genes · 2019Article
- Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers.Metabolism open · 2019Article
- Magnetic Resonance Imaging of the Musculoskeletal System at 7T: Morphological Imaging and Beyond.Topics in magnetic resonance imaging : TMRI · 2019Review
- Adipose Insulin Resistance in Normal-Weight Women With Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2019Article
- Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.American journal of physiology. Endocrinology and metabolism · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
Hyperandrogenic syndrome (HAS) is associated with insulin resistance (IR) and type 2 diabetes. Muscle IR in type 2 diabetes is linked with defects in mitochondrial oxidative capacity. In vivo muscle mitochondrial function has not been studied in HAS, especially in youth, who are early in the disease process. Our goal was to measure muscle mitochondrial oxidative function and peripheral IR in obese youth with HAS. Obese girls without HAS [n = 22, age 15(13,17) yr, BMI Z-score 2.05 ± 0.37] and with HAS [n = 35, age 15(14,16) yr, BMI Z-score 2.18 ± 0.30] were enrolled. Mitochondrial function was assessed with (31)phosphorus MR spectroscopy before, during, and after near-maximal isometric calf exercise, and peripheral IR was assessed with an 80 mU·m(-2)·min(-1) hyperinsulinemic euglycemic clamp. Girls with HAS had higher androgens [free androgen index 7.9(6.6,15.5) vs. 3.5(3.0,4.0), P < 0.01] and more IR [glucose infusion rate 9.4(7.0, 12,2) vs. 14.5(13.2,15.8) mg·kg lean(-1)·min(-1), P < 0.01]. HAS girls also had increased markers of inflammation including CRP, platelets, and white blood cell count and higher serum free fatty acids during hyperinsulinemia. Mitochondrial oxidative phosphorylation was lower in HAS [0.11(0.06,0.19) vs. 0.18(0.12,0.23) mmol/s, P < 0.05], although other spectroscopy markers of mitochondrial function were similar between groups. In multivariate analysis of the entire cohort, IR related to androgens, oxidative phosphorylation, and free fatty acid concentrations during hyperinsulinemia. These relationships were present in just the HAS cohort as well. Obese girls with HAS have significant peripheral IR, which is related to elevated androgens and free fatty acids and decreased mitochondrial oxidative phosphorylation. These may provide future options as targets for therapeutic intervention.
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